diff --git a/ci-targets.yaml b/ci-targets.yaml
index cd892ac9..9c23f9b6 100644
--- a/ci-targets.yaml
+++ b/ci-targets.yaml
@@ -51,7 +51,7 @@ linux:
     build_options:
       - debug
       - noopt
-      - lto
+      - pgo+lto
     build_options_conditional:
       - options:
           - freethreaded+debug
@@ -72,7 +72,7 @@ linux:
     build_options:
       - debug
       - noopt
-      - lto
+      - pgo+lto
     build_options_conditional:
       - options:
           - freethreaded+debug
@@ -93,7 +93,7 @@ linux:
     build_options:
       - debug
       - noopt
-      - lto
+      - pgo+lto
     build_options_conditional:
       - options:
           - freethreaded+debug
@@ -114,7 +114,7 @@ linux:
     build_options:
       - debug
       - noopt
-      - lto
+      - pgo+lto
     build_options_conditional:
       - options:
           - freethreaded+debug
@@ -135,7 +135,7 @@ linux:
     build_options:
       - debug
       - noopt
-      - lto
+      - pgo+lto
     build_options_conditional:
       - options:
           - freethreaded+debug
@@ -156,7 +156,7 @@ linux:
     build_options:
       - debug
       - noopt
-      - lto
+      - pgo+lto
     build_options_conditional:
       - options:
           - freethreaded+debug
@@ -262,7 +262,7 @@ linux:
       - lto+static
       - debug
       - noopt
-      - lto
+      - pgo+lto
     run: true
 
   x86_64_v2-unknown-linux-musl:
@@ -281,7 +281,7 @@ linux:
       - lto+static
       - debug
       - noopt
-      - lto
+      - pgo+lto
     run: true
 
   x86_64_v3-unknown-linux-musl:
@@ -300,7 +300,7 @@ linux:
       - lto+static
       - debug
       - noopt
-      - lto
+      - pgo+lto
     run: true
 
   x86_64_v4-unknown-linux-musl:
@@ -319,7 +319,7 @@ linux:
       - lto+static
       - debug
       - noopt
-      - lto
+      - pgo+lto
     run: true
 
 windows:
diff --git a/cpython-unix/build-cpython.sh b/cpython-unix/build-cpython.sh
index 5e66f053..fa0d25bc 100755
--- a/cpython-unix/build-cpython.sh
+++ b/cpython-unix/build-cpython.sh
@@ -431,8 +431,8 @@ if [ -n "${CPYTHON_OPTIMIZED}" ]; then
         CONFIGURE_FLAGS="${CONFIGURE_FLAGS} --enable-bolt"
     fi
 
-    # Allow users to enable the experimental JIT on 3.13+
-    if [[ -n "${PYTHON_MEETS_MINIMUM_VERSION_3_13}" ]]; then
+    # Allow users to enable the experimental JIT on 3.13+ (but not on musl)
+    if [[ -n "${PYTHON_MEETS_MINIMUM_VERSION_3_13}" && ! "${CC}" = "musl-clang" ]]; then
 
         # The JIT build is failing on macOS due to compiler errors
         # Only enable on Linux / 3.13 until that's fixed upstream