diff --git a/pyproject.toml b/pyproject.toml
index 7d325e5..11bec85 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -34,6 +34,7 @@ classifiers = [
 ]
 dependencies = [
     "typer >= 0.12.3",
+    "tomli >= 2.0.1; python_version < '3.11'",
 ]
 
 [project.optional-dependencies]
diff --git a/src/fastapi_cli/cli.py b/src/fastapi_cli/cli.py
index d5bcb8e..e607feb 100644
--- a/src/fastapi_cli/cli.py
+++ b/src/fastapi_cli/cli.py
@@ -12,6 +12,7 @@
 from fastapi_cli.exceptions import FastAPICLIException
 
 from . import __version__
+from .config import CommandWithProjectConfig
 from .logging import setup_logging
 
 app = typer.Typer(rich_markup_mode="rich")
@@ -100,12 +101,13 @@ def _run(
     )
 
 
-@app.command()
+@app.command(cls=CommandWithProjectConfig)
 def dev(
     path: Annotated[
         Union[Path, None],
         typer.Argument(
-            help="A path to a Python file or package directory (with [blue]__init__.py[/blue] files) containing a [bold]FastAPI[/bold] app. If not provided, a default set of paths will be tried."
+            help="A path to a Python file or package directory (with [blue]__init__.py[/blue] files) containing a [bold]FastAPI[/bold] app. If not provided, a default set of paths will be tried.",
+            envvar=["FASTAPI_DEV_PATH", "FASTAPI_PATH"],
         ),
     ] = None,
     *,
@@ -183,12 +185,13 @@ def dev(
     )
 
 
-@app.command()
+@app.command(cls=CommandWithProjectConfig)
 def run(
     path: Annotated[
         Union[Path, None],
         typer.Argument(
-            help="A path to a Python file or package directory (with [blue]__init__.py[/blue] files) containing a [bold]FastAPI[/bold] app. If not provided, a default set of paths will be tried."
+            help="A path to a Python file or package directory (with [blue]__init__.py[/blue] files) containing a [bold]FastAPI[/bold] app. If not provided, a default set of paths will be tried.",
+            envvar=["FASTAPI_RUN_PATH", "FASTAPI_PATH"],
         ),
     ] = None,
     *,
@@ -274,4 +277,4 @@ def run(
 
 
 def main() -> None:
-    app()
+    app(auto_envvar_prefix="FASTAPI")
diff --git a/src/fastapi_cli/config.py b/src/fastapi_cli/config.py
new file mode 100644
index 0000000..5a2ec8f
--- /dev/null
+++ b/src/fastapi_cli/config.py
@@ -0,0 +1,95 @@
+from __future__ import annotations
+
+import logging
+import sys
+from pathlib import Path
+from typing import Any, Sequence
+
+from click import BadParameter, Context
+from typer.core import TyperCommand
+
+if sys.version_info >= (3, 11):
+    import tomllib
+else:
+    import tomli as tomllib
+
+logger = logging.getLogger(__name__)
+
+
+def get_toml_key(config: dict[str, Any], keys: Sequence[str]) -> dict[str, Any]:
+    for key in keys:
+        config = config.get(key, {})
+    return config
+
+
+def read_pyproject_file(keys: Sequence[str]) -> dict[str, Any] | None:
+    path = Path("pyproject.toml")
+    if not path.exists():
+        return None
+
+    with path.open("rb") as f:
+        data = tomllib.load(f)
+
+    config = get_toml_key(data, keys)
+    return config or None
+
+
+class CommandWithProjectConfig(TyperCommand):
+    """Command class which loads parameters from a pyproject.toml file.
+
+    The table `tool.fastapi.cli` will be used. An additional subtable for the
+    running command will also be used. e.g. `tool.fastapi.cli.dev`. Options
+    on subcommand tables will override options from the cli table.
+
+    Example:
+
+    ```toml
+    [tool.fastapi.cli]
+    path = "asgi.py"
+    app = "application"
+
+    [tool.fastapi.cli.dev]
+    host = "0.0.0.0"
+    port = 5000
+
+    [tool.fastapi.cli.run]
+    reload = true
+    ```
+    """
+
+    toml_keys = ("tool", "fastapi", "cli")
+
+    def load_config_table(
+        self,
+        ctx: Context,
+        config: dict[str, Any],
+        config_path: str | None = None,
+    ) -> None:
+        if config_path is not None:
+            config = config.get(config_path, {})
+        if not config:
+            return
+        for param in ctx.command.params:
+            param_name = param.name or ""
+            if param_name in config:
+                try:
+                    value = param.type_cast_value(ctx, config[param_name])
+                except (TypeError, BadParameter) as e:
+                    keys: list[str] = list(self.toml_keys)
+                    if config_path is not None:
+                        keys.append(config_path)
+                    keys.append(param_name)
+                    full_path = ".".join(keys)
+                    ctx.fail(f"Error parsing pyproject.toml: key '{full_path}': {e}")
+                else:
+                    ctx.params[param_name] = value
+
+    def invoke(self, ctx: Context) -> Any:
+        config = read_pyproject_file(self.toml_keys)
+        if config is not None:
+            logger.info("Loading configuration from pyproject.toml")
+            command_name = ctx.command.name or ""
+            self.load_config_table(ctx, config)
+            self.load_config_table(ctx, config, command_name)
+
+        return super().invoke(ctx)
diff --git a/tests/assets/projects/bad_configured_app/app.py b/tests/assets/projects/bad_configured_app/app.py
new file mode 100644
index 0000000..6cdf1de
--- /dev/null
+++ b/tests/assets/projects/bad_configured_app/app.py
@@ -0,0 +1,8 @@
+from fastapi import FastAPI
+
+app = FastAPI()
+
+
+@app.get("/")
+def app_root():
+    return {"message": "badly configured app"}
diff --git a/tests/assets/projects/bad_configured_app/pyproject.toml b/tests/assets/projects/bad_configured_app/pyproject.toml
new file mode 100644
index 0000000..75cbbbf
--- /dev/null
+++ b/tests/assets/projects/bad_configured_app/pyproject.toml
@@ -0,0 +1,2 @@
+[tool.fastapi.cli.run]
+port = "http"
diff --git a/tests/assets/projects/configured_app/pyproject.toml b/tests/assets/projects/configured_app/pyproject.toml
new file mode 100644
index 0000000..5f1f4f0
--- /dev/null
+++ b/tests/assets/projects/configured_app/pyproject.toml
@@ -0,0 +1,3 @@
+[tool.fastapi.cli]
+path = "server.py"
+app = "application"
diff --git a/tests/assets/projects/configured_app/server.py b/tests/assets/projects/configured_app/server.py
new file mode 100644
index 0000000..2364e73
--- /dev/null
+++ b/tests/assets/projects/configured_app/server.py
@@ -0,0 +1,8 @@
+from fastapi import FastAPI
+
+application = FastAPI()
+
+
+@application.get("/")
+def app_root():
+    return {"message": "configured app"}
diff --git a/tests/assets/projects/configured_app_subtable/app.py b/tests/assets/projects/configured_app_subtable/app.py
new file mode 100644
index 0000000..b5b10be
--- /dev/null
+++ b/tests/assets/projects/configured_app_subtable/app.py
@@ -0,0 +1,8 @@
+from fastapi import FastAPI
+
+app = FastAPI()
+
+
+@app.get("/")
+def app_root():
+    return {"message": "configured app with subcommand config"}
diff --git a/tests/assets/projects/configured_app_subtable/pyproject.toml b/tests/assets/projects/configured_app_subtable/pyproject.toml
new file mode 100644
index 0000000..ea56896
--- /dev/null
+++ b/tests/assets/projects/configured_app_subtable/pyproject.toml
@@ -0,0 +1,11 @@
+[tool.fastapi.cli]
+# global option
+port = 8001
+
+[tool.fastapi.cli.run]
+reload = true
+workers = 4
+
+[tool.fastapi.cli.dev]
+# overrides global option
+port = 8002
diff --git a/tests/conftest.py b/tests/conftest.py
index 955fd22..6ca44a4 100644
--- a/tests/conftest.py
+++ b/tests/conftest.py
@@ -1,10 +1,14 @@
+import inspect
 import sys
+from pathlib import Path
 from typing import Generator
 
 import pytest
 from fastapi_cli.logging import setup_logging
 from typer import rich_utils
 
+assets_path = Path(__file__).parent / "assets"
+
 
 @pytest.fixture(autouse=True)
 def reset_syspath() -> Generator[None, None, None]:
@@ -21,3 +25,23 @@ def setup_terminal() -> None:
     rich_utils.FORCE_TERMINAL = False
     setup_logging(terminal_width=3000)
     return
+
+
+@pytest.fixture(autouse=True)
+def asset_import_cleaner() -> Generator[None, None, None]:
+    existing_imports = set(sys.modules.keys())
+    try:
+        yield
+    finally:
+        # clean up imports
+        new_imports = set(sys.modules.keys()) ^ existing_imports
+        for name in new_imports:
+            try:
+                mod_file = inspect.getfile(sys.modules[name])
+            except TypeError:  # pragma: no cover
+                # builtin, ignore
+                pass
+            else:
+                # only clean up imports from the test directory
+                if mod_file.startswith(str(assets_path)):
+                    del sys.modules[name]
diff --git a/tests/test_cli.py b/tests/test_cli.py
index 44c14d2..2caac63 100644
--- a/tests/test_cli.py
+++ b/tests/test_cli.py
@@ -1,8 +1,12 @@
+from __future__ import annotations
+
 import subprocess
 import sys
 from pathlib import Path
+from typing import Any
 from unittest.mock import patch
 
+import pytest
 import uvicorn
 from fastapi_cli.cli import app
 from typer.testing import CliRunner
@@ -82,6 +86,47 @@ def test_dev_args() -> None:
         assert "│  fastapi run" in result.output
 
 
+def test_project_run() -> None:
+    with changing_dir(assets_path / "projects/configured_app"):
+        with patch.object(uvicorn, "run") as mock_run:
+            result = runner.invoke(app, ["run"])
+            assert result.exit_code == 0, result.output
+            assert mock_run.called
+            assert mock_run.call_args
+            assert mock_run.call_args.kwargs == {
+                "app": "server:application",
+                "host": "0.0.0.0",
+                "port": 8000,
+                "reload": False,
+                "workers": None,
+                "root_path": "",
+                "proxy_headers": True,
+            }
+
+
+@pytest.mark.parametrize(
+    ("command", "kwargs"),
+    [
+        ("run", {"host": "0.0.0.0", "port": 8001, "workers": 4}),
+        ("dev", {"host": "127.0.0.1", "port": 8002, "workers": None}),
+    ],
+)
+def test_project_run_subconfigure(command: str, kwargs: dict[str, Any]) -> None:
+    with changing_dir(assets_path / "projects/configured_app_subtable"):
+        with patch.object(uvicorn, "run") as mock_run:
+            result = runner.invoke(app, [command])
+            assert result.exit_code == 0, result.output
+            assert mock_run.called
+            assert mock_run.call_args
+            assert mock_run.call_args.kwargs == {
+                "app": "app:app",
+                "reload": True,
+                "root_path": "",
+                "proxy_headers": True,
+                **kwargs,
+            }
+
+
 def test_run() -> None:
     with changing_dir(assets_path):
         with patch.object(uvicorn, "run") as mock_run:
@@ -159,6 +204,16 @@ def test_run_error() -> None:
         assert "Path does not exist non_existing_file.py" in result.output
 
 
+def test_project_config_error() -> None:
+    with changing_dir(assets_path / "projects/bad_configured_app"):
+        result = runner.invoke(app, ["run"])
+        assert result.exit_code == 2, result.output
+        assert (
+            "Error parsing pyproject.toml: key 'tool.fastapi.cli.run.port'"
+            in result.output
+        )
+
+
 def test_dev_help() -> None:
     result = runner.invoke(app, ["dev", "--help"])
     assert result.exit_code == 0, result.output