diff --git a/llvm/lib/Transforms/Vectorize/VPlanConstruction.cpp b/llvm/lib/Transforms/Vectorize/VPlanConstruction.cpp
index b374371667b5e..5eb2f058f329f 100644
--- a/llvm/lib/Transforms/Vectorize/VPlanConstruction.cpp
+++ b/llvm/lib/Transforms/Vectorize/VPlanConstruction.cpp
@@ -386,33 +386,54 @@ std::unique_ptr<VPlan> VPlanTransforms::buildPlainCFG(
 /// Checks if \p HeaderVPB is a loop header block in the plain CFG; that is, it
 /// has exactly 2 predecessors (preheader and latch), where the block
 /// dominates the latch and the preheader dominates the block. If it is a
-/// header block return true, making sure the preheader appears first and
-/// the latch second. Otherwise return false.
-static bool canonicalHeader(VPBlockBase *HeaderVPB,
-                            const VPDominatorTree &VPDT) {
+/// header block return true and canonicalize the predecessors of the header
+/// (making sure the preheader appears first and the latch second) and the
+/// successors of the latch (making sure the loop exit comes first). Otherwise
+/// return false.
+static bool canonicalHeaderAndLatch(VPBlockBase *HeaderVPB,
+                                    const VPDominatorTree &VPDT) {
   ArrayRef<VPBlockBase *> Preds = HeaderVPB->getPredecessors();
   if (Preds.size() != 2)
     return false;
 
   auto *PreheaderVPBB = Preds[0];
   auto *LatchVPBB = Preds[1];
-  if (VPDT.dominates(PreheaderVPBB, HeaderVPB) &&
-      VPDT.dominates(HeaderVPB, LatchVPBB))
-    return true;
+  if (!VPDT.dominates(PreheaderVPBB, HeaderVPB) ||
+      !VPDT.dominates(HeaderVPB, LatchVPBB)) {
+    std::swap(PreheaderVPBB, LatchVPBB);
 
-  std::swap(PreheaderVPBB, LatchVPBB);
+    if (!VPDT.dominates(PreheaderVPBB, HeaderVPB) ||
+        !VPDT.dominates(HeaderVPB, LatchVPBB))
+      return false;
 
-  if (VPDT.dominates(PreheaderVPBB, HeaderVPB) &&
-      VPDT.dominates(HeaderVPB, LatchVPBB)) {
-    // Canonicalize predecessors of header so that preheader is first and latch
-    // second.
+    // Canonicalize predecessors of header so that preheader is first and
+    // latch second.
     HeaderVPB->swapPredecessors();
     for (VPRecipeBase &R : cast<VPBasicBlock>(HeaderVPB)->phis())
       R.swapOperands();
-    return true;
   }
 
-  return false;
+  // The two successors of conditional branch match the condition, with the
+  // first successor corresponding to true and the second to false. We
+  // canonicalize the successors of the latch when introducing the region, such
+  // that the latch exits the region when its condition is true; invert the
+  // original condition if the original CFG branches to the header on true.
+  // Note that the exit edge is not yet connected for top-level loops.
+  if (LatchVPBB->getSingleSuccessor() ||
+      LatchVPBB->getSuccessors()[0] != HeaderVPB)
+    return true;
+
+  assert(LatchVPBB->getNumSuccessors() == 2 && "Must have 2 successors");
+  auto *Term = cast<VPBasicBlock>(LatchVPBB)->getTerminator();
+  assert(cast<VPInstruction>(Term)->getOpcode() ==
+             VPInstruction::BranchOnCond &&
+         "terminator must be a BranchOnCond");
+  auto *Not = new VPInstruction(VPInstruction::Not, {Term->getOperand(0)});
+  Not->insertBefore(Term);
+  Term->setOperand(0, Not);
+  LatchVPBB->swapSuccessors();
+
+  return true;
 }
 
 /// Create a new VPRegionBlock for the loop starting at \p HeaderVPB.
@@ -447,7 +468,7 @@ void VPlanTransforms::createLoopRegions(VPlan &Plan, Type *InductionTy,
   VPDominatorTree VPDT;
   VPDT.recalculate(Plan);
   for (VPBlockBase *HeaderVPB : vp_depth_first_shallow(Plan.getEntry()))
-    if (canonicalHeader(HeaderVPB, VPDT))
+    if (canonicalHeaderAndLatch(HeaderVPB, VPDT))
       createLoopRegion(Plan, HeaderVPB);
 
   VPRegionBlock *TopRegion = Plan.getVectorLoopRegion();
diff --git a/llvm/test/Transforms/LoopVectorize/outer-loop-inner-latch-successors.ll b/llvm/test/Transforms/LoopVectorize/outer-loop-inner-latch-successors.ll
index 388da8540646f..afd1308a2d24a 100644
--- a/llvm/test/Transforms/LoopVectorize/outer-loop-inner-latch-successors.ll
+++ b/llvm/test/Transforms/LoopVectorize/outer-loop-inner-latch-successors.ll
@@ -4,7 +4,6 @@
 @A = common global [1024 x i64] zeroinitializer, align 16
 @B = common global [1024 x i64] zeroinitializer, align 16
 
-; FIXME: The exit condition of the inner loop is incorrect when vectorizing.
 define void @inner_latch_header_first_successor(i64 %N, i32 %c, i64 %M) {
 ; CHECK-LABEL: define void @inner_latch_header_first_successor(
 ; CHECK-SAME: i64 [[N:%.*]], i32 [[C:%.*]], i64 [[M:%.*]]) {
@@ -35,8 +34,9 @@ define void @inner_latch_header_first_successor(i64 %N, i32 %c, i64 %M) {
 ; CHECK-NEXT:    [[TMP3]] = add nsw <4 x i64> [[TMP2]], [[VEC_PHI4]]
 ; CHECK-NEXT:    [[TMP4]] = add nuw nsw <4 x i64> [[VEC_PHI]], splat (i64 1)
 ; CHECK-NEXT:    [[TMP5:%.*]] = icmp ne <4 x i64> [[TMP4]], [[BROADCAST_SPLAT2]]
-; CHECK-NEXT:    [[TMP6:%.*]] = extractelement <4 x i1> [[TMP5]], i32 0
-; CHECK-NEXT:    br i1 [[TMP6]], label %[[VECTOR_LATCH]], label %[[INNER3]]
+; CHECK-NEXT:    [[TMP6:%.*]] = xor <4 x i1> [[TMP5]], splat (i1 true)
+; CHECK-NEXT:    [[TMP9:%.*]] = extractelement <4 x i1> [[TMP6]], i32 0
+; CHECK-NEXT:    br i1 [[TMP9]], label %[[VECTOR_LATCH]], label %[[INNER3]]
 ; CHECK:       [[VECTOR_LATCH]]:
 ; CHECK-NEXT:    [[VEC_PHI6:%.*]] = phi <4 x i64> [ [[TMP3]], %[[INNER3]] ]
 ; CHECK-NEXT:    call void @llvm.masked.scatter.v4i64.v4p0(<4 x i64> [[VEC_PHI6]], <4 x ptr> [[TMP0]], i32 4, <4 x i1> splat (i1 true))