diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index 3cbc0bc877..69f9d25ee6 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -6,7 +6,7 @@ on:
     - 'release/*'
   pull_request:
 env:
-  CORE_REPO_SHA: 05d251c5d6baefe2f084e7361cb144c4fa10da96
+  CORE_REPO_SHA: c09f2076a1878c6d58b78d3895485ef5559f30f7
 
 jobs:
   build:
@@ -42,7 +42,7 @@ jobs:
           path: |
             .tox
             ~/.cache/pip
-          key: v6-build-tox-cache-${{ env.RUN_MATRIX_COMBINATION }}-${{ hashFiles('tox.ini', 'gen-requirements.txt', 'dev-requirements.txt') }}
+          key: v7-build-tox-cache-${{ env.RUN_MATRIX_COMBINATION }}-${{ hashFiles('tox.ini', 'gen-requirements.txt', 'dev-requirements.txt') }}
       - name: run tox
         run: tox -f ${{ matrix.python-version }}-${{ matrix.package }} -- --benchmark-json=${{ env.RUN_MATRIX_COMBINATION }}-benchmark.json
   #     - name: Find and merge ${{ matrix.package }} benchmarks
@@ -118,7 +118,7 @@ jobs:
           path: |
             .tox
             ~/.cache/pip
-          key: v6-misc-tox-cache-${{ matrix.tox-environment }}-${{ hashFiles('tox.ini', 'dev-requirements.txt', 'gen-requirements.txt', 'docs-requirements.txt') }}
+          key: v7-misc-tox-cache-${{ matrix.tox-environment }}-${{ hashFiles('tox.ini', 'dev-requirements.txt', 'gen-requirements.txt', 'docs-requirements.txt') }}
       - name: run tox
         run: tox -e ${{ matrix.tox-environment }}
       - name: Ensure generated code is up to date
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg2/tests/test_psycopg2_integration.py b/instrumentation/opentelemetry-instrumentation-psycopg2/tests/test_psycopg2_integration.py
index e974da7d60..f516a07882 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg2/tests/test_psycopg2_integration.py
+++ b/instrumentation/opentelemetry-instrumentation-psycopg2/tests/test_psycopg2_integration.py
@@ -68,6 +68,7 @@ def get_dsn_parameters(self):  # pylint: disable=no-self-use
 
 class TestPostgresqlIntegration(TestBase):
     def setUp(self):
+        super().setUp()
         self.cursor_mock = mock.patch(
             "opentelemetry.instrumentation.psycopg2.pg_cursor", MockCursor
         )
diff --git a/instrumentation/opentelemetry-instrumentation-pymongo/src/opentelemetry/instrumentation/pymongo/__init__.py b/instrumentation/opentelemetry-instrumentation-pymongo/src/opentelemetry/instrumentation/pymongo/__init__.py
index 171979dbfe..ba3afae11f 100644
--- a/instrumentation/opentelemetry-instrumentation-pymongo/src/opentelemetry/instrumentation/pymongo/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-pymongo/src/opentelemetry/instrumentation/pymongo/__init__.py
@@ -223,7 +223,6 @@ def _instrument(self, **kwargs):
         request_hook = kwargs.get("request_hook", dummy_callback)
         response_hook = kwargs.get("response_hook", dummy_callback)
         failed_hook = kwargs.get("failed_hook", dummy_callback)
-
         # Create and register a CommandTracer only the first time
         if self._commandtracer_instance is None:
             tracer = get_tracer(__name__, __version__, tracer_provider)
@@ -235,7 +234,6 @@ def _instrument(self, **kwargs):
                 failed_hook=failed_hook,
             )
             monitoring.register(self._commandtracer_instance)
-
         # If already created, just enable it
         self._commandtracer_instance.is_enabled = True
 
diff --git a/instrumentation/opentelemetry-instrumentation-redis/tests/test_redis.py b/instrumentation/opentelemetry-instrumentation-redis/tests/test_redis.py
index 3780f0c245..3d5479e731 100644
--- a/instrumentation/opentelemetry-instrumentation-redis/tests/test_redis.py
+++ b/instrumentation/opentelemetry-instrumentation-redis/tests/test_redis.py
@@ -21,9 +21,16 @@
 
 
 class TestRedis(TestBase):
+    def setUp(self):
+        super().setUp()
+        RedisInstrumentor().instrument(tracer_provider=self.tracer_provider)
+
+    def tearDown(self):
+        super().tearDown()
+        RedisInstrumentor().uninstrument()
+
     def test_span_properties(self):
         redis_client = redis.Redis()
-        RedisInstrumentor().instrument(tracer_provider=self.tracer_provider)
 
         with mock.patch.object(redis_client, "connection"):
             redis_client.get("key")
@@ -36,7 +43,6 @@ def test_span_properties(self):
 
     def test_not_recording(self):
         redis_client = redis.Redis()
-        RedisInstrumentor().instrument(tracer_provider=self.tracer_provider)
 
         mock_tracer = mock.Mock()
         mock_span = mock.Mock()
@@ -53,7 +59,6 @@ def test_not_recording(self):
 
     def test_instrument_uninstrument(self):
         redis_client = redis.Redis()
-        RedisInstrumentor().instrument(tracer_provider=self.tracer_provider)
 
         with mock.patch.object(redis_client, "connection"):
             redis_client.get("key")
diff --git a/instrumentation/opentelemetry-instrumentation-remoulade/tests/test_messages.py b/instrumentation/opentelemetry-instrumentation-remoulade/tests/test_messages.py
index 4704111bdd..ff25b3f6de 100644
--- a/instrumentation/opentelemetry-instrumentation-remoulade/tests/test_messages.py
+++ b/instrumentation/opentelemetry-instrumentation-remoulade/tests/test_messages.py
@@ -35,6 +35,10 @@ def setUp(self):
 
         broker.declare_actor(actor_div)
 
+    def tearDown(self):
+        RemouladeInstrumentor().uninstrument()
+        super().tearDown()
+
     def test_message(self):
         actor_div.send(2, 3)
 
diff --git a/instrumentation/opentelemetry-instrumentation-sqlite3/tests/test_sqlite3.py b/instrumentation/opentelemetry-instrumentation-sqlite3/tests/test_sqlite3.py
index 714ca0ea02..581920232b 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlite3/tests/test_sqlite3.py
+++ b/instrumentation/opentelemetry-instrumentation-sqlite3/tests/test_sqlite3.py
@@ -21,30 +21,26 @@
 
 
 class TestSQLite3(TestBase):
-    @classmethod
-    def setUpClass(cls):
-        super().setUpClass()
-        cls._connection = None
-        cls._cursor = None
-        cls._connection2 = None
-        cls._cursor2 = None
-        cls._tracer = cls.tracer_provider.get_tracer(__name__)
-        SQLite3Instrumentor().instrument(tracer_provider=cls.tracer_provider)
-        cls._connection = sqlite3.connect(":memory:")
-        cls._cursor = cls._connection.cursor()
-        cls._connection2 = dbapi2.connect(":memory:")
-        cls._cursor2 = cls._connection2.cursor()
+    def setUp(self):
+        super().setUp()
+        SQLite3Instrumentor().instrument(tracer_provider=self.tracer_provider)
+        self._tracer = self.tracer_provider.get_tracer(__name__)
+        self._connection = sqlite3.connect(":memory:")
+        self._cursor = self._connection.cursor()
+        self._connection2 = dbapi2.connect(":memory:")
+        self._cursor2 = self._connection2.cursor()
 
-    @classmethod
-    def tearDownClass(cls):
-        if cls._cursor:
-            cls._cursor.close()
-        if cls._connection:
-            cls._connection.close()
-        if cls._cursor2:
-            cls._cursor2.close()
-        if cls._connection2:
-            cls._connection2.close()
+    def tearDown(self):
+        super().tearDown()
+        if self._cursor:
+            self._cursor.close()
+        if self._connection:
+            self._connection.close()
+        if self._cursor2:
+            self._cursor2.close()
+        if self._connection2:
+            self._connection2.close()
+        SQLite3Instrumentor().uninstrument()
 
     def validate_spans(self, span_name):
         spans = self.memory_exporter.get_finished_spans()
@@ -65,6 +61,12 @@ def validate_spans(self, span_name):
         self.assertIs(child_span.parent, root_span.get_span_context())
         self.assertIs(child_span.kind, trace_api.SpanKind.CLIENT)
 
+    def _create_tables(self):
+        stmt = "CREATE TABLE IF NOT EXISTS test (id integer)"
+        self._cursor.execute(stmt)
+        self._cursor2.execute(stmt)
+        self.memory_exporter.clear()
+
     def test_execute(self):
         """Should create a child span for execute method"""
         stmt = "CREATE TABLE IF NOT EXISTS test (id integer)"
@@ -78,6 +80,9 @@ def test_execute(self):
 
     def test_executemany(self):
         """Should create a child span for executemany"""
+        self._create_tables()
+
+        # real spans for executemany
         stmt = "INSERT INTO test (id) VALUES (?)"
         data = [("1",), ("2",), ("3",)]
         with self._tracer.start_as_current_span("rootSpan"):
diff --git a/instrumentation/opentelemetry-instrumentation-wsgi/tests/test_wsgi_middleware.py b/instrumentation/opentelemetry-instrumentation-wsgi/tests/test_wsgi_middleware.py
index 7bdfabc37f..eeaad4c3cb 100644
--- a/instrumentation/opentelemetry-instrumentation-wsgi/tests/test_wsgi_middleware.py
+++ b/instrumentation/opentelemetry-instrumentation-wsgi/tests/test_wsgi_middleware.py
@@ -508,8 +508,7 @@ def test_mark_span_internal_in_presence_of_span_from_other_framework(self):
 class TestAdditionOfCustomRequestResponseHeaders(WsgiTestBase):
     def setUp(self):
         super().setUp()
-        tracer_provider, _ = TestBase.create_tracer_provider()
-        self.tracer = tracer_provider.get_tracer(__name__)
+        self.tracer = self.tracer_provider.get_tracer(__name__)
 
     def iterate_response(self, response):
         while True:
diff --git a/opentelemetry-instrumentation/tests/test_dependencies.py b/opentelemetry-instrumentation/tests/test_dependencies.py
index a8acac62f4..04bcf476ea 100644
--- a/opentelemetry-instrumentation/tests/test_dependencies.py
+++ b/opentelemetry-instrumentation/tests/test_dependencies.py
@@ -26,9 +26,6 @@
 
 
 class TestDependencyConflicts(TestBase):
-    def setUp(self):
-        pass
-
     def test_get_dependency_conflicts_empty(self):
         self.assertIsNone(get_dependency_conflicts([]))
 
diff --git a/opentelemetry-instrumentation/tests/test_propagators.py b/opentelemetry-instrumentation/tests/test_propagators.py
index 62461aafa9..00ec65a128 100644
--- a/opentelemetry-instrumentation/tests/test_propagators.py
+++ b/opentelemetry-instrumentation/tests/test_propagators.py
@@ -14,6 +14,8 @@
 
 # pylint: disable=protected-access
 
+import unittest
+
 from opentelemetry import trace
 from opentelemetry.instrumentation import propagators
 from opentelemetry.instrumentation.propagators import (
@@ -39,7 +41,7 @@ def test_get_set(self):
         propagators._RESPONSE_PROPAGATOR = original
 
 
-class TestDictHeaderSetter(TestBase):
+class TestDictHeaderSetter(unittest.TestCase):
     def test_simple(self):
         setter = DictHeaderSetter()
         carrier = {}
diff --git a/opentelemetry-instrumentation/tests/test_utils.py b/opentelemetry-instrumentation/tests/test_utils.py
index b7c9ecdc6e..e6fe80a347 100644
--- a/opentelemetry-instrumentation/tests/test_utils.py
+++ b/opentelemetry-instrumentation/tests/test_utils.py
@@ -12,17 +12,17 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
+import unittest
 from http import HTTPStatus
 
 from opentelemetry.instrumentation.utils import (
     _python_path_without_directory,
     http_status_to_status_code,
 )
-from opentelemetry.test.test_base import TestBase
 from opentelemetry.trace import StatusCode
 
 
-class TestUtils(TestBase):
+class TestUtils(unittest.TestCase):
     # See https://github.com/open-telemetry/opentelemetry-specification/blob/main/specification/trace/semantic_conventions/http.md#status
     def test_http_status_to_status_code(self):
         for status_code, expected in (
diff --git a/tests/opentelemetry-docker-tests/tests/asyncpg/test_asyncpg_functional.py b/tests/opentelemetry-docker-tests/tests/asyncpg/test_asyncpg_functional.py
index 9470f68b05..8111bce15e 100644
--- a/tests/opentelemetry-docker-tests/tests/asyncpg/test_asyncpg_functional.py
+++ b/tests/opentelemetry-docker-tests/tests/asyncpg/test_asyncpg_functional.py
@@ -21,14 +21,11 @@ def async_call(coro):
 
 
 class TestFunctionalAsyncPG(TestBase):
-    @classmethod
-    def setUpClass(cls):
-        super().setUpClass()
-        cls._connection = None
-        cls._cursor = None
-        cls._tracer = cls.tracer_provider.get_tracer(__name__)
-        AsyncPGInstrumentor().instrument(tracer_provider=cls.tracer_provider)
-        cls._connection = async_call(
+    def setUp(self):
+        super().setUp()
+        self._tracer = self.tracer_provider.get_tracer(__name__)
+        AsyncPGInstrumentor().instrument(tracer_provider=self.tracer_provider)
+        self._connection = async_call(
             asyncpg.connect(
                 database=POSTGRES_DB_NAME,
                 user=POSTGRES_USER,
@@ -38,9 +35,9 @@ def setUpClass(cls):
             )
         )
 
-    @classmethod
-    def tearDownClass(cls):
+    def tearDown(self):
         AsyncPGInstrumentor().uninstrument()
+        super().tearDown()
 
     def check_span(self, span):
         self.assertEqual(
@@ -148,16 +145,13 @@ def test_instrumented_method_doesnt_capture_parameters(self, *_, **__):
 
 
 class TestFunctionalAsyncPG_CaptureParameters(TestBase):
-    @classmethod
-    def setUpClass(cls):
-        super().setUpClass()
-        cls._connection = None
-        cls._cursor = None
-        cls._tracer = cls.tracer_provider.get_tracer(__name__)
+    def setUp(self):
+        super().setUp()
+        self._tracer = self.tracer_provider.get_tracer(__name__)
         AsyncPGInstrumentor(capture_parameters=True).instrument(
-            tracer_provider=cls.tracer_provider
+            tracer_provider=self.tracer_provider
         )
-        cls._connection = async_call(
+        self._connection = async_call(
             asyncpg.connect(
                 database=POSTGRES_DB_NAME,
                 user=POSTGRES_USER,
@@ -167,9 +161,9 @@ def setUpClass(cls):
             )
         )
 
-    @classmethod
-    def tearDownClass(cls):
+    def tearDown(self):
         AsyncPGInstrumentor().uninstrument()
+        super().tearDown()
 
     def check_span(self, span):
         self.assertEqual(
diff --git a/tests/opentelemetry-docker-tests/tests/mysql/test_mysql_functional.py b/tests/opentelemetry-docker-tests/tests/mysql/test_mysql_functional.py
index 59cf401e03..4f1305e866 100644
--- a/tests/opentelemetry-docker-tests/tests/mysql/test_mysql_functional.py
+++ b/tests/opentelemetry-docker-tests/tests/mysql/test_mysql_functional.py
@@ -29,22 +29,10 @@
 
 
 class TestFunctionalMysql(TestBase):
-    @classmethod
-    def setUpClass(cls):
-        super().setUpClass()
-        cls._connection = None
-        cls._cursor = None
-        cls._tracer = cls.tracer_provider.get_tracer(__name__)
-        MySQLInstrumentor().instrument()
-
-    @classmethod
-    def tearDownClass(cls):
-        if cls._connection:
-            cls._connection.close()
-        MySQLInstrumentor().uninstrument()
-
     def setUp(self):
         super().setUp()
+        self._tracer = self.tracer_provider.get_tracer(__name__)
+        MySQLInstrumentor().instrument()
         self._connection = mysql.connector.connect(
             user=MYSQL_USER,
             password=MYSQL_PASSWORD,
@@ -54,6 +42,12 @@ def setUp(self):
         )
         self._cursor = self._connection.cursor()
 
+    def tearDown(self):
+        self._cursor.close()
+        self._connection.close()
+        MySQLInstrumentor().uninstrument()
+        super().tearDown()
+
     def validate_spans(self, span_name):
         spans = self.memory_exporter.get_finished_spans()
         self.assertEqual(len(spans), 2)
diff --git a/tests/opentelemetry-docker-tests/tests/postgres/test_aiopg_functional.py b/tests/opentelemetry-docker-tests/tests/postgres/test_aiopg_functional.py
index 5f1d20bdc1..8157c06a32 100644
--- a/tests/opentelemetry-docker-tests/tests/postgres/test_aiopg_functional.py
+++ b/tests/opentelemetry-docker-tests/tests/postgres/test_aiopg_functional.py
@@ -36,14 +36,11 @@ def async_call(coro):
 
 
 class TestFunctionalAiopgConnect(TestBase):
-    @classmethod
-    def setUpClass(cls):
-        super().setUpClass()
-        cls._connection = None
-        cls._cursor = None
-        cls._tracer = cls.tracer_provider.get_tracer(__name__)
-        AiopgInstrumentor().instrument(tracer_provider=cls.tracer_provider)
-        cls._connection = async_call(
+    def setUp(self):
+        super().setUp()
+        self._tracer = self.tracer_provider.get_tracer(__name__)
+        AiopgInstrumentor().instrument(tracer_provider=self.tracer_provider)
+        self._connection = async_call(
             aiopg.connect(
                 dbname=POSTGRES_DB_NAME,
                 user=POSTGRES_USER,
@@ -52,15 +49,13 @@ def setUpClass(cls):
                 port=POSTGRES_PORT,
             )
         )
-        cls._cursor = async_call(cls._connection.cursor())
-
-    @classmethod
-    def tearDownClass(cls):
-        if cls._cursor:
-            cls._cursor.close()
-        if cls._connection:
-            cls._connection.close()
+        self._cursor = async_call(self._connection.cursor())
+
+    def tearDown(self):
+        self._cursor.close()
+        self._connection.close()
         AiopgInstrumentor().uninstrument()
+        super().tearDown()
 
     def validate_spans(self, span_name):
         spans = self.memory_exporter.get_finished_spans()
@@ -121,18 +116,15 @@ def test_callproc(self):
 
 
 class TestFunctionalAiopgCreatePool(TestBase):
-    @classmethod
-    def setUpClass(cls):
-        super().setUpClass()
-        cls._connection = None
-        cls._cursor = None
-        cls._tracer = cls.tracer_provider.get_tracer(__name__)
-        AiopgInstrumentor().instrument(tracer_provider=cls.tracer_provider)
-        cls._dsn = (
+    def setUp(self):
+        super().setUp()
+        self._tracer = self.tracer_provider.get_tracer(__name__)
+        AiopgInstrumentor().instrument(tracer_provider=self.tracer_provider)
+        self._dsn = (
             f"dbname='{POSTGRES_DB_NAME}' user='{POSTGRES_USER}' password='{POSTGRES_PASSWORD}'"
             f" host='{POSTGRES_HOST}' port='{POSTGRES_PORT}'"
         )
-        cls._pool = async_call(
+        self._pool = async_call(
             aiopg.create_pool(
                 dbname=POSTGRES_DB_NAME,
                 user=POSTGRES_USER,
@@ -141,18 +133,15 @@ def setUpClass(cls):
                 port=POSTGRES_PORT,
             )
         )
-        cls._connection = async_call(cls._pool.acquire())
-        cls._cursor = async_call(cls._connection.cursor())
-
-    @classmethod
-    def tearDownClass(cls):
-        if cls._cursor:
-            cls._cursor.close()
-        if cls._connection:
-            cls._connection.close()
-        if cls._pool:
-            cls._pool.close()
+        self._connection = async_call(self._pool.acquire())
+        self._cursor = async_call(self._connection.cursor())
+
+    def tearDown(self):
+        self._cursor.close()
+        self._connection.close()
+        self._pool.close()
         AiopgInstrumentor().uninstrument()
+        super().tearDown()
 
     def validate_spans(self, span_name):
         spans = self.memory_exporter.get_finished_spans()
diff --git a/tests/opentelemetry-docker-tests/tests/postgres/test_psycopg_functional.py b/tests/opentelemetry-docker-tests/tests/postgres/test_psycopg_functional.py
index 38ecff02e7..53112a5dbd 100644
--- a/tests/opentelemetry-docker-tests/tests/postgres/test_psycopg_functional.py
+++ b/tests/opentelemetry-docker-tests/tests/postgres/test_psycopg_functional.py
@@ -30,30 +30,25 @@
 
 
 class TestFunctionalPsycopg(TestBase):
-    @classmethod
-    def setUpClass(cls):
-        super().setUpClass()
-        cls._connection = None
-        cls._cursor = None
-        cls._tracer = cls.tracer_provider.get_tracer(__name__)
-        Psycopg2Instrumentor().instrument(tracer_provider=cls.tracer_provider)
-        cls._connection = psycopg2.connect(
+    def setUp(self):
+        super().setUp()
+        self._tracer = self.tracer_provider.get_tracer(__name__)
+        Psycopg2Instrumentor().instrument(tracer_provider=self.tracer_provider)
+        self._connection = psycopg2.connect(
             dbname=POSTGRES_DB_NAME,
             user=POSTGRES_USER,
             password=POSTGRES_PASSWORD,
             host=POSTGRES_HOST,
             port=POSTGRES_PORT,
         )
-        cls._connection.set_session(autocommit=True)
-        cls._cursor = cls._connection.cursor()
-
-    @classmethod
-    def tearDownClass(cls):
-        if cls._cursor:
-            cls._cursor.close()
-        if cls._connection:
-            cls._connection.close()
+        self._connection.set_session(autocommit=True)
+        self._cursor = self._connection.cursor()
+
+    def tearDown(self):
+        self._cursor.close()
+        self._connection.close()
         Psycopg2Instrumentor().uninstrument()
+        super().tearDown()
 
     def validate_spans(self, span_name):
         spans = self.memory_exporter.get_finished_spans()
diff --git a/tests/opentelemetry-docker-tests/tests/postgres/test_psycopg_sqlcommenter.py b/tests/opentelemetry-docker-tests/tests/postgres/test_psycopg_sqlcommenter.py
index 1e3460600e..9c84792256 100644
--- a/tests/opentelemetry-docker-tests/tests/postgres/test_psycopg_sqlcommenter.py
+++ b/tests/opentelemetry-docker-tests/tests/postgres/test_psycopg_sqlcommenter.py
@@ -26,30 +26,25 @@
 
 
 class TestFunctionalPsycopg(TestBase):
-    @classmethod
-    def setUpClass(cls):
-        super().setUpClass()
-        cls._connection = None
-        cls._cursor = None
-        cls._tracer = cls.tracer_provider.get_tracer(__name__)
+    def setUp(self):
+        super().setUp()
+        self._tracer = self.tracer_provider.get_tracer(__name__)
         Psycopg2Instrumentor().instrument(enable_commenter=True)
-        cls._connection = psycopg2.connect(
+        self._connection = psycopg2.connect(
             dbname=POSTGRES_DB_NAME,
             user=POSTGRES_USER,
             password=POSTGRES_PASSWORD,
             host=POSTGRES_HOST,
             port=POSTGRES_PORT,
         )
-        cls._connection.set_session(autocommit=True)
-        cls._cursor = cls._connection.cursor()
+        self._connection.set_session(autocommit=True)
+        self._cursor = self._connection.cursor()
 
-    @classmethod
-    def tearDownClass(cls):
-        if cls._cursor:
-            cls._cursor.close()
-        if cls._connection:
-            cls._connection.close()
+    def tearDown(self):
+        self._cursor.close()
+        self._connection.close()
         Psycopg2Instrumentor().uninstrument()
+        super().tearDown()
 
     def test_commenter_enabled(self):
         self._cursor.execute("SELECT  1;")
diff --git a/tests/opentelemetry-docker-tests/tests/pymongo/test_pymongo_functional.py b/tests/opentelemetry-docker-tests/tests/pymongo/test_pymongo_functional.py
index a716cd8def..92c694953b 100644
--- a/tests/opentelemetry-docker-tests/tests/pymongo/test_pymongo_functional.py
+++ b/tests/opentelemetry-docker-tests/tests/pymongo/test_pymongo_functional.py
@@ -28,16 +28,21 @@
 
 
 class TestFunctionalPymongo(TestBase):
-    @classmethod
-    def setUpClass(cls):
-        super().setUpClass()
-        cls._tracer = cls.tracer_provider.get_tracer(__name__)
-        PymongoInstrumentor().instrument()
+    def setUp(self):
+        super().setUp()
+        self._tracer = self.tracer_provider.get_tracer(__name__)
+        self.instrumentor = PymongoInstrumentor()
+        self.instrumentor.instrument()
+        self.instrumentor._commandtracer_instance._tracer = self._tracer
         client = MongoClient(
             MONGODB_HOST, MONGODB_PORT, serverSelectionTimeoutMS=2000
         )
         db = client[MONGODB_DB_NAME]
-        cls._collection = db[MONGODB_COLLECTION_NAME]
+        self._collection = db[MONGODB_COLLECTION_NAME]
+
+    def tearDown(self):
+        self.instrumentor.uninstrument()
+        super().tearDown()
 
     def validate_spans(self):
         spans = self.memory_exporter.get_finished_spans()
diff --git a/tests/opentelemetry-docker-tests/tests/pymysql/test_pymysql_functional.py b/tests/opentelemetry-docker-tests/tests/pymysql/test_pymysql_functional.py
index 881ef05d2a..83f7abf281 100644
--- a/tests/opentelemetry-docker-tests/tests/pymysql/test_pymysql_functional.py
+++ b/tests/opentelemetry-docker-tests/tests/pymysql/test_pymysql_functional.py
@@ -29,27 +29,24 @@
 
 
 class TestFunctionalPyMysql(TestBase):
-    @classmethod
-    def setUpClass(cls):
-        super().setUpClass()
-        cls._connection = None
-        cls._cursor = None
-        cls._tracer = cls.tracer_provider.get_tracer(__name__)
+    def setUp(self):
+        super().setUp()
+        self._tracer = self.tracer_provider.get_tracer(__name__)
         PyMySQLInstrumentor().instrument()
-        cls._connection = pymy.connect(
+        self._connection = pymy.connect(
             user=MYSQL_USER,
             password=MYSQL_PASSWORD,
             host=MYSQL_HOST,
             port=MYSQL_PORT,
             database=MYSQL_DB_NAME,
         )
-        cls._cursor = cls._connection.cursor()
+        self._cursor = self._connection.cursor()
 
-    @classmethod
-    def tearDownClass(cls):
-        if cls._connection:
-            cls._connection.close()
+    def tearDown(self):
+        self._cursor.close()
+        self._connection.close()
         PyMySQLInstrumentor().uninstrument()
+        super().tearDown()
 
     def validate_spans(self, span_name):
         spans = self.memory_exporter.get_finished_spans()
diff --git a/tests/opentelemetry-docker-tests/tests/redis/test_redis_functional.py b/tests/opentelemetry-docker-tests/tests/redis/test_redis_functional.py
index 6a4ef5021c..21d7e36b00 100644
--- a/tests/opentelemetry-docker-tests/tests/redis/test_redis_functional.py
+++ b/tests/opentelemetry-docker-tests/tests/redis/test_redis_functional.py
@@ -31,8 +31,8 @@ def setUp(self):
         RedisInstrumentor().instrument(tracer_provider=self.tracer_provider)
 
     def tearDown(self):
-        super().tearDown()
         RedisInstrumentor().uninstrument()
+        super().tearDown()
 
     def _check_span(self, span, name):
         self.assertEqual(span.name, name)
@@ -203,8 +203,8 @@ def setUp(self):
         RedisInstrumentor().instrument(tracer_provider=self.tracer_provider)
 
     def tearDown(self):
-        super().tearDown()
         RedisInstrumentor().uninstrument()
+        super().tearDown()
 
     def _check_span(self, span, name):
         self.assertEqual(span.name, name)
@@ -383,8 +383,8 @@ def setUp(self):
         RedisInstrumentor().instrument(tracer_provider=self.tracer_provider)
 
     def tearDown(self):
-        super().tearDown()
         RedisInstrumentor().uninstrument()
+        super().tearDown()
 
     def _check_span(self, span, name):
         self.assertEqual(span.name, name)
diff --git a/tests/opentelemetry-docker-tests/tests/sqlalchemy_tests/test_instrument.py b/tests/opentelemetry-docker-tests/tests/sqlalchemy_tests/test_instrument.py
index 8c97d100e0..48944d58e0 100644
--- a/tests/opentelemetry-docker-tests/tests/sqlalchemy_tests/test_instrument.py
+++ b/tests/opentelemetry-docker-tests/tests/sqlalchemy_tests/test_instrument.py
@@ -35,6 +35,7 @@ class SQLAlchemyInstrumentTestCase(TestBase):
     """
 
     def setUp(self):
+        super().setUp()
         # create a traced engine with the given arguments
         SQLAlchemyInstrumentor().instrument()
         dsn = (
@@ -45,23 +46,23 @@ def setUp(self):
 
         # prepare a connection
         self.conn = self.engine.connect()
-        super().setUp()
 
     def tearDown(self):
         # clear the database and dispose the engine
         self.conn.close()
         self.engine.dispose()
         SQLAlchemyInstrumentor().uninstrument()
+        super().tearDown()
 
     def test_engine_traced(self):
         # ensures that the engine is traced
         rows = self.conn.execute("SELECT").fetchall()
         self.assertEqual(len(rows), 1)
 
-        traces = self.memory_exporter.get_finished_spans()
+        spans = self.memory_exporter.get_finished_spans()
         # trace composition
-        self.assertEqual(len(traces), 1)
-        span = traces[0]
+        self.assertEqual(len(spans), 2)
+        span = spans[1]
         # check subset of span fields
         self.assertEqual(span.name, "SELECT opentelemetry-tests")
         self.assertIs(span.status.status_code, trace.StatusCode.UNSET)
diff --git a/util/opentelemetry-util-http/tests/test_capture_custom_headers.py b/util/opentelemetry-util-http/tests/test_capture_custom_headers.py
index eb1a4f6a7e..e6e1583ffb 100644
--- a/util/opentelemetry-util-http/tests/test_capture_custom_headers.py
+++ b/util/opentelemetry-util-http/tests/test_capture_custom_headers.py
@@ -12,9 +12,9 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
+import unittest
 from unittest.mock import patch
 
-from opentelemetry.test.test_base import TestBase
 from opentelemetry.util.http import (
     OTEL_INSTRUMENTATION_HTTP_CAPTURE_HEADERS_SERVER_REQUEST,
     OTEL_INSTRUMENTATION_HTTP_CAPTURE_HEADERS_SERVER_RESPONSE,
@@ -24,7 +24,7 @@
 )
 
 
-class TestCaptureCustomHeaders(TestBase):
+class TestCaptureCustomHeaders(unittest.TestCase):
     @patch.dict(
         "os.environ",
         {
diff --git a/util/opentelemetry-util-http/tests/test_http_excluded_urls.py b/util/opentelemetry-util-http/tests/test_http_excluded_urls.py
index af524d2e7b..3fea381050 100644
--- a/util/opentelemetry-util-http/tests/test_http_excluded_urls.py
+++ b/util/opentelemetry-util-http/tests/test_http_excluded_urls.py
@@ -12,13 +12,13 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
+import unittest
 from unittest.mock import patch
 
-from opentelemetry.test.test_base import TestBase
 from opentelemetry.util.http import get_excluded_urls
 
 
-class TestGetExcludedUrls(TestBase):
+class TestGetExcludedUrls(unittest.TestCase):
     @patch.dict(
         "os.environ",
         {