diff --git a/CHANGELOG.md b/CHANGELOG.md
index c5ce56423a..3dd53582ec 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -7,23 +7,25 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ## Unreleased
 
-## Added
+### Added
 
 - `opentelemetry-instrumentation-kafka-python` Instrument temporary fork, kafka-python-ng
   inside kafka-python's instrumentation
   ([#2537](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2537))
 
-## Breaking changes
+### Breaking changes
 
 - `opentelemetry-bootstrap` Remove `opentelemetry-instrumentation-aws-lambda` from the defaults instrumentations
   ([#2786](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2786))
 
-## Fixed
+### Fixed
 
+- `opentelemetry-instrumentation-httpx` fix handling of async hooks
+  ([#2823](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2823))
 - `opentelemetry-instrumentation-system-metrics` fix `process.runtime.cpu.utilization` values to be shown in range of 0 to 1
-  ([2812](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2812))
+  ([#2812](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2812))
 - `opentelemetry-instrumentation-fastapi` fix `fastapi` auto-instrumentation by removing `fastapi-slim` support, `fastapi-slim` itself is discontinued from maintainers
-  ([2783](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2783))
+  ([#2783](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2783))
 - `opentelemetry-instrumentation-aws-lambda` Avoid exception when a handler is not present.
   ([#2750](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2750))
 - `opentelemetry-instrumentation-django` Fix regression - `http.target` re-added back to old semconv duration metrics
diff --git a/instrumentation/opentelemetry-instrumentation-httpx/src/opentelemetry/instrumentation/httpx/__init__.py b/instrumentation/opentelemetry-instrumentation-httpx/src/opentelemetry/instrumentation/httpx/__init__.py
index 43db6c3a82..15ee59a183 100644
--- a/instrumentation/opentelemetry-instrumentation-httpx/src/opentelemetry/instrumentation/httpx/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-httpx/src/opentelemetry/instrumentation/httpx/__init__.py
@@ -192,6 +192,7 @@ async def async_response_hook(span, request, response):
 """
 import logging
 import typing
+from asyncio import iscoroutinefunction
 from types import TracebackType
 
 import httpx
@@ -731,15 +732,19 @@ def _instrument(self, **kwargs):
         self._original_async_client = httpx.AsyncClient
         request_hook = kwargs.get("request_hook")
         response_hook = kwargs.get("response_hook")
-        async_request_hook = kwargs.get("async_request_hook", request_hook)
-        async_response_hook = kwargs.get("async_response_hook", response_hook)
+        async_request_hook = kwargs.get("async_request_hook")
+        async_response_hook = kwargs.get("async_response_hook")
         if callable(request_hook):
             _InstrumentedClient._request_hook = request_hook
-        if callable(async_request_hook):
+        if callable(async_request_hook) and iscoroutinefunction(
+            async_request_hook
+        ):
             _InstrumentedAsyncClient._request_hook = async_request_hook
         if callable(response_hook):
             _InstrumentedClient._response_hook = response_hook
-        if callable(async_response_hook):
+        if callable(async_response_hook) and iscoroutinefunction(
+            async_response_hook
+        ):
             _InstrumentedAsyncClient._response_hook = async_response_hook
         tracer_provider = kwargs.get("tracer_provider")
         _InstrumentedClient._tracer_provider = tracer_provider
diff --git a/instrumentation/opentelemetry-instrumentation-httpx/tests/test_httpx_integration.py b/instrumentation/opentelemetry-instrumentation-httpx/tests/test_httpx_integration.py
index 011b5e57d2..78938eb337 100644
--- a/instrumentation/opentelemetry-instrumentation-httpx/tests/test_httpx_integration.py
+++ b/instrumentation/opentelemetry-instrumentation-httpx/tests/test_httpx_integration.py
@@ -780,9 +780,15 @@ def test_custom_tracer_provider(self):
             HTTPXClientInstrumentor().uninstrument()
 
         def test_response_hook(self):
+            response_hook_key = (
+                "async_response_hook"
+                if asyncio.iscoroutinefunction(self.response_hook)
+                else "response_hook"
+            )
+            response_hook_kwargs = {response_hook_key: self.response_hook}
             HTTPXClientInstrumentor().instrument(
                 tracer_provider=self.tracer_provider,
-                response_hook=self.response_hook,
+                **response_hook_kwargs,
             )
             client = self.create_client()
             result = self.perform_request(self.URL, client=client)
@@ -823,9 +829,15 @@ def test_response_hook_sync_async_kwargs(self):
             HTTPXClientInstrumentor().uninstrument()
 
         def test_request_hook(self):
+            request_hook_key = (
+                "async_request_hook"
+                if asyncio.iscoroutinefunction(self.request_hook)
+                else "request_hook"
+            )
+            request_hook_kwargs = {request_hook_key: self.request_hook}
             HTTPXClientInstrumentor().instrument(
                 tracer_provider=self.tracer_provider,
-                request_hook=self.request_hook,
+                **request_hook_kwargs,
             )
             client = self.create_client()
             result = self.perform_request(self.URL, client=client)
@@ -1214,3 +1226,36 @@ def test_basic_multiple(self):
         self.perform_request(self.URL, client=self.client)
         self.perform_request(self.URL, client=self.client2)
         self.assert_span(num_spans=2)
+
+    def test_async_response_hook_does_nothing_if_not_coroutine(self):
+        HTTPXClientInstrumentor().instrument(
+            tracer_provider=self.tracer_provider,
+            async_response_hook=_response_hook,
+        )
+        client = self.create_client()
+        result = self.perform_request(self.URL, client=client)
+
+        self.assertEqual(result.text, "Hello!")
+        span = self.assert_span()
+        self.assertEqual(
+            dict(span.attributes),
+            {
+                SpanAttributes.HTTP_METHOD: "GET",
+                SpanAttributes.HTTP_URL: self.URL,
+                SpanAttributes.HTTP_STATUS_CODE: 200,
+            },
+        )
+        HTTPXClientInstrumentor().uninstrument()
+
+    def test_async_request_hook_does_nothing_if_not_coroutine(self):
+        HTTPXClientInstrumentor().instrument(
+            tracer_provider=self.tracer_provider,
+            async_request_hook=_request_hook,
+        )
+        client = self.create_client()
+        result = self.perform_request(self.URL, client=client)
+
+        self.assertEqual(result.text, "Hello!")
+        span = self.assert_span()
+        self.assertEqual(span.name, "GET")
+        HTTPXClientInstrumentor().uninstrument()