diff --git a/instrumentation/opentelemetry-instrumentation-boto/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-boto/test-requirements.txt
index bb56100ecb..41c228a1fe 100644
--- a/instrumentation/opentelemetry-instrumentation-boto/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-boto/test-requirements.txt
@@ -5,7 +5,7 @@ botocore==1.34.44
 certifi==2024.7.4
 cffi==1.17.0
 charset-normalizer==3.3.2
-cryptography==42.0.5
+cryptography==43.0.1
 Deprecated==1.2.14
 docker==7.0.0
 idna==3.7
diff --git a/instrumentation/opentelemetry-instrumentation-botocore/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-botocore/test-requirements.txt
index f0ceb9f467..e5e698c1cf 100644
--- a/instrumentation/opentelemetry-instrumentation-botocore/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-botocore/test-requirements.txt
@@ -5,7 +5,7 @@ botocore==1.31.80
 certifi==2024.7.4
 cffi==1.17.0
 charset-normalizer==3.3.2
-cryptography==42.0.5
+cryptography==43.0.1
 Deprecated==1.2.14
 docker==7.0.0
 idna==3.7