diff --git a/CHANGELOG.md b/CHANGELOG.md
index cc7a26bb789..f379f34e0de 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -7,6 +7,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ## Unreleased
 
+- Fix intermittent `Connection aborted` error when using otlp/http exporters
+  ([#4477](https://github.com/open-telemetry/opentelemetry-python/pull/4477))
 - opentelemetry-sdk: use stable code attributes: `code.function` -> `code.function.name`, `code.lineno` -> `code.line.number`, `code.filepath` -> `code.file.path`
   ([#4508](https://github.com/open-telemetry/opentelemetry-python/pull/4508))
 - Fix serialization of extended attributes for logs signal
diff --git a/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/_log_exporter/__init__.py b/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/_log_exporter/__init__.py
index 21b877380c8..f86f0113833 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/_log_exporter/__init__.py
+++ b/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/_log_exporter/__init__.py
@@ -21,6 +21,7 @@
 from typing import Dict, Optional, Sequence
 
 import requests
+from requests.exceptions import ConnectionError
 
 from opentelemetry.exporter.otlp.proto.common._internal import (
     _create_exp_backoff_generator,
@@ -133,13 +134,27 @@ def _export(self, serialized_data: bytes):
         elif self._compression == Compression.Deflate:
             data = zlib.compress(serialized_data)
 
-        return self._session.post(
-            url=self._endpoint,
-            data=data,
-            verify=self._certificate_file,
-            timeout=self._timeout,
-            cert=self._client_cert,
-        )
+        # By default, keep-alive is enabled in Session's request
+        # headers. Backends may choose to close the connection
+        # while a post happens which causes an unhandled
+        # exception. This try/except will retry the post on such exceptions
+        try:
+            resp = self._session.post(
+                url=self._endpoint,
+                data=data,
+                verify=self._certificate_file,
+                timeout=self._timeout,
+                cert=self._client_cert,
+            )
+        except ConnectionError:
+            resp = self._session.post(
+                url=self._endpoint,
+                data=data,
+                verify=self._certificate_file,
+                timeout=self._timeout,
+                cert=self._client_cert,
+            )
+        return resp
 
     @staticmethod
     def _retryable(resp: requests.Response) -> bool:
diff --git a/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/metric_exporter/__init__.py b/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/metric_exporter/__init__.py
index 00f429e4c97..4feea8d4302 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/metric_exporter/__init__.py
+++ b/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/metric_exporter/__init__.py
@@ -29,6 +29,7 @@
 
 import requests
 from deprecated import deprecated
+from requests.exceptions import ConnectionError
 
 from opentelemetry.exporter.otlp.proto.common._internal import (
     _create_exp_backoff_generator,
@@ -175,13 +176,27 @@ def _export(self, serialized_data: bytes):
         elif self._compression == Compression.Deflate:
             data = zlib.compress(serialized_data)
 
-        return self._session.post(
-            url=self._endpoint,
-            data=data,
-            verify=self._certificate_file,
-            timeout=self._timeout,
-            cert=self._client_cert,
-        )
+        # By default, keep-alive is enabled in Session's request
+        # headers. Backends may choose to close the connection
+        # while a post happens which causes an unhandled
+        # exception. This try/except will retry the post on such exceptions
+        try:
+            resp = self._session.post(
+                url=self._endpoint,
+                data=data,
+                verify=self._certificate_file,
+                timeout=self._timeout,
+                cert=self._client_cert,
+            )
+        except ConnectionError:
+            resp = self._session.post(
+                url=self._endpoint,
+                data=data,
+                verify=self._certificate_file,
+                timeout=self._timeout,
+                cert=self._client_cert,
+            )
+        return resp
 
     @staticmethod
     def _retryable(resp: requests.Response) -> bool:
diff --git a/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/trace_exporter/__init__.py b/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/trace_exporter/__init__.py
index 7bcf4b4ced1..1841e5210a4 100644
--- a/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/trace_exporter/__init__.py
+++ b/exporter/opentelemetry-exporter-otlp-proto-http/src/opentelemetry/exporter/otlp/proto/http/trace_exporter/__init__.py
@@ -21,6 +21,7 @@
 from typing import Dict, Optional
 
 import requests
+from requests.exceptions import ConnectionError
 
 from opentelemetry.exporter.otlp.proto.common._internal import (
     _create_exp_backoff_generator,
@@ -130,13 +131,27 @@ def _export(self, serialized_data: bytes):
         elif self._compression == Compression.Deflate:
             data = zlib.compress(serialized_data)
 
-        return self._session.post(
-            url=self._endpoint,
-            data=data,
-            verify=self._certificate_file,
-            timeout=self._timeout,
-            cert=self._client_cert,
-        )
+        # By default, keep-alive is enabled in Session's request
+        # headers. Backends may choose to close the connection
+        # while a post happens which causes an unhandled
+        # exception. This try/except will retry the post on such exceptions
+        try:
+            resp = self._session.post(
+                url=self._endpoint,
+                data=data,
+                verify=self._certificate_file,
+                timeout=self._timeout,
+                cert=self._client_cert,
+            )
+        except ConnectionError:
+            resp = self._session.post(
+                url=self._endpoint,
+                data=data,
+                verify=self._certificate_file,
+                timeout=self._timeout,
+                cert=self._client_cert,
+            )
+        return resp
 
     @staticmethod
     def _retryable(resp: requests.Response) -> bool: