diff --git a/lib/redis_client/cluster.rb b/lib/redis_client/cluster.rb
index 02281105..dd397e17 100644
--- a/lib/redis_client/cluster.rb
+++ b/lib/redis_client/cluster.rb
@@ -1,6 +1,7 @@
 # frozen_string_literal: true
 
 require 'redis_client/cluster/concurrent_worker'
+require 'redis_client/cluster/pinned_connection_delegator'
 require 'redis_client/cluster/pipeline'
 require 'redis_client/cluster/pub_sub'
 require 'redis_client/cluster/router'
@@ -93,7 +94,7 @@ def multi(watch: nil, &block)
       ::RedisClient::Cluster::Transaction.new(@router, @command_builder).execute(watch: watch, &block)
     end
 
-    def with(key: nil, hashtag: nil, write: true, retry_count: 0, &block)
+    def with(key: nil, hashtag: nil, write: true, retry_count: 0)
       key = process_with_arguments(key, hashtag)
 
       node_key = @router.find_node_key_by_key(key, primary: write)
@@ -101,7 +102,13 @@ def with(key: nil, hashtag: nil, write: true, retry_count: 0, &block)
       # Calling #with checks out the underlying connection if this is a pooled connection
       # Calling it through #try_delegate ensures we handle any redirections and retry the entire
       # transaction if so.
-      @router.try_delegate(node, :with, retry_count: retry_count, &block)
+      @router.try_delegate(node, :with, retry_count: retry_count) do |raw_client|
+        if @config.client_side_slot_validation
+          yield PinnedConnectionDelegator.new(raw_client, locked_key_slot: key, cluster_commands: @router.cluster_commands)
+        else
+          yield raw_client
+        end
+      end
     end
 
     def pubsub
diff --git a/lib/redis_client/cluster/pinned_connection_delegator.rb b/lib/redis_client/cluster/pinned_connection_delegator.rb
new file mode 100644
index 00000000..3c547482
--- /dev/null
+++ b/lib/redis_client/cluster/pinned_connection_delegator.rb
@@ -0,0 +1,80 @@
+# frozen_string_literal: true
+
+require 'delegate'
+class RedisClient
+  class Cluster
+    class PinnedConnectionDelegator < SimpleDelegator
+      METHOD_WRAPPERS = {
+        # These methods return a Pipeline or Multi to the yielded block which itself
+        # requires wrapping.
+        %i[pipelined multi] => lambda do |*args, **kwargs, &block|
+          super(*args, **kwargs, &wrap_yielded_object(block))
+        end,
+        # These are various commanding methods, each of which has a different signature
+        # which we need to understand to extract the commands properly
+        %i[call call_once] => lambda do |*command, **kwargs, &block|
+          validate_slot! command
+          super(*command, **kwargs, &block)
+        end,
+        %i[call_v call_once_v] => lambda do |command, &block|
+          validate_slot! command
+          super command, &block
+        end,
+        %i[blocking_call] => lambda do |timeout, *command, **kwargs, &block|
+          validate_slot! command
+          super timeout, *command, **kwargs, &block
+        end,
+        %i[blocking_call_v] => lambda do |timeout, command, &block|
+          validate_slot! command
+          super timeout, command, &block
+        end
+      }.freeze
+
+      def initialize(connection, locked_key_slot:, cluster_commands:)
+        @locked_key_slot = locked_key_slot
+        @cluster_commands = cluster_commands
+        super(connection)
+
+        # Set up the slot validation for the set of methods which this object
+        # implements. Note that we might be wrapping a RedisClient, RedisClient::Multi,
+        # or RedisClient::Pipeline object, and they do not all respond to the same set of
+        # methods. Hence, we need to dynamically detect what we're wrapping and define
+        # the correct methods.
+        METHOD_WRAPPERS.each do |methods, impl|
+          methods.each do |method|
+            define_singleton_method(method, &impl) if respond_to?(method)
+          end
+        end
+      end
+
+      private
+
+      def validate_slot!(command)
+        keys = @cluster_commands.extract_all_keys(command)
+        key_slots = keys.map { |k| ::RedisClient::Cluster::KeySlotConverter.convert(k) }
+        locked_slot = ::RedisClient::Cluster::KeySlotConverter.convert(@locked_key_slot)
+
+        return if key_slots.all? { |slot| slot ==  locked_slot }
+
+        key_slot_pairs = keys.zip(key_slots).map { |key, slot| "#{key} => #{slot}" }.join(', ')
+        raise ::RedisClient::Cluster::Transaction::ConsistencyError, <<~MESSAGE
+          Connection is pinned to slot #{locked_slot} (via key #{@locked_key_slot}). \
+          However, command #{command.inspect} has keys hashing to slots #{key_slot_pairs}. \
+          Transactions in redis cluster must only refer to keys hashing to the same slot.
+        MESSAGE
+      end
+
+      # This method ensures that calls to #pipelined, #multi, etc wrap yielded redis-callable objects
+      # back in the pinning delegator
+      def wrap_yielded_object(orig_block)
+        return nil if orig_block.nil?
+
+        proc do |clientish|
+          orig_block.call(
+            self.class.new(clientish, locked_key_slot: @locked_key_slot, cluster_commands: @cluster_commands)
+          )
+        end
+      end
+    end
+  end
+end
diff --git a/lib/redis_client/cluster/router.rb b/lib/redis_client/cluster/router.rb
index 7fa37d15..4472a6de 100644
--- a/lib/redis_client/cluster/router.rb
+++ b/lib/redis_client/cluster/router.rb
@@ -188,6 +188,10 @@ def command_exists?(name)
         @command.exists?(name)
       end
 
+      def cluster_commands
+        @command
+      end
+
       def assign_redirection_node(err_msg)
         _, slot, node_key = err_msg.split
         slot = slot.to_i
diff --git a/lib/redis_client/cluster_config.rb b/lib/redis_client/cluster_config.rb
index 78455b49..b5fe0c6c 100644
--- a/lib/redis_client/cluster_config.rb
+++ b/lib/redis_client/cluster_config.rb
@@ -24,9 +24,9 @@ class ClusterConfig
     InvalidClientConfigError = Class.new(::RedisClient::Error)
 
     attr_reader :command_builder, :client_config, :replica_affinity, :slow_command_timeout,
-                :connect_with_original_config, :startup_nodes
+                :connect_with_original_config, :startup_nodes, :client_side_slot_validation
 
-    def initialize(
+    def initialize( # rubocop:disable Metrics/ParameterLists
       nodes: DEFAULT_NODES,
       replica: false,
       replica_affinity: :random,
@@ -36,6 +36,7 @@ def initialize(
       client_implementation: ::RedisClient::Cluster, # for redis gem
       slow_command_timeout: SLOW_COMMAND_TIMEOUT,
       command_builder: ::RedisClient::CommandBuilder,
+      client_side_slot_validation: true,
       **client_config
     )
 
@@ -51,6 +52,7 @@ def initialize(
       @connect_with_original_config = connect_with_original_config
       @client_implementation = client_implementation
       @slow_command_timeout = slow_command_timeout
+      @client_side_slot_validation = client_side_slot_validation
     end
 
     def inspect
diff --git a/test/redis_client/test_cluster.rb b/test/redis_client/test_cluster.rb
index 433a9af6..b771c997 100644
--- a/test/redis_client/test_cluster.rb
+++ b/test/redis_client/test_cluster.rb
@@ -533,8 +533,6 @@ def test_pinning_two_keys
       end
 
       def test_pinning_cross_slot
-        skip 'This is not implemented yet!'
-
         assert_raises(::RedisClient::Cluster::Transaction::ConsistencyError) do
           @client.with(hashtag: 'slot1') do |conn|
             conn.call('GET', '{slot2}')
@@ -542,6 +540,23 @@ def test_pinning_cross_slot
         end
       end
 
+      def test_pinning_cross_slot_without_validation
+        client = new_test_client(client_side_slot_validation: false)
+        assert_raises(::RedisClient::CommandError) do
+          client.with(hashtag: 'slot1') do |conn|
+            conn.call('GET', '{slot2}')
+          end
+        end
+      end
+
+      def test_pinning_blocking_call
+        got = @client.with(key: 'key1') do |conn|
+          conn.blocking_call(1, 'SET', 'key1', 'hello')
+          conn.blocking_call_v(1, %w[GET key1])
+        end
+        assert_equal('hello', got)
+      end
+
       def test_pinning_hashtag_with_braces
         got = @client.with(hashtag: '{slot}') do |conn|
           conn.call('SET', '{slot}key1', 'v1')
@@ -565,6 +580,16 @@ def test_pinning_pipeline
         assert_equal(3, got)
       end
 
+      def test_pinning_pipeline_cross_slot
+        assert_raises(::RedisClient::Cluster::Transaction::ConsistencyError) do
+          @client.with(hashtag: 'slot1') do |conn|
+            conn.pipelined do |pipe|
+              pipe.call('GET', '{slot2}foo')
+            end
+          end
+        end
+      end
+
       def test_pinning_pipeline_with_error
         assert_raises(RedisClient::CommandError) do
           @client.with(hashtag: 'slot') do |conn|
@@ -591,6 +616,30 @@ def test_pinning_transaction
         assert_equal(%w[OK OK], got)
       end
 
+      def test_pinning_transaction_cross_slot
+        assert_raises(::RedisClient::Cluster::Transaction::ConsistencyError) do
+          @client.with(hashtag: 'slot1') do |conn|
+            conn.multi do |txn|
+              txn.call('GET', '{slot2}foo')
+            end
+          end
+        end
+      end
+
+      def test_pinning_multi_does_not_respond_to_blocking
+        @client.with(hashtag: 'slot1') do |conn|
+          assert_respond_to conn, :blocking_call_v
+          conn.multi do |txn|
+            refute_respond_to txn.__getobj__, :blocking_call_v
+            refute_respond_to txn, :blocking_call_v
+            # i.e. does not raise Transaction::ConsistencyError
+            assert_raises(NoMethodError) do
+              txn.blocking_call_v('SET', '{slot}key1', 'value1')
+            end
+          end
+        end
+      end
+
       def test_pinning_transaction_watch_arg
         @client.call('MSET', '{slot}key1', 'val1', '{slot}key2', 'val2')
         @captured_commands.clear
@@ -669,6 +718,19 @@ def test_pinning_transaction_can_unwatch_manually
         assert_equal('OK', got)
       end
 
+      def test_pinning_transaction_can_coerce_with_block
+        @client.call('MSET', '{slot}key1', 1, '{slot}key2', 2)
+        got = @client.with(hashtag: 'slot') do |conn|
+          conn.multi do |txn|
+            # This tests a RedisClient behaviour where blocks can be used to modify the return results
+            # of multi/pipeliend blocks
+            txn.call('GET', '{slot}key1') { |res| res.to_i + 5 }
+            txn.call_v(['GET', '{slot}key2']) { |res| res.to_i + 2 }
+          end
+        end
+        assert_equal([6, 4], got)
+      end
+
       def test_pinning_timeouts_update_topology
         # Create a new test client with a lower timeout for this test so it's fast.
         captured_commands = CommandCaptureMiddleware::CommandBuffer.new