diff --git a/src/core/components/execute.jsx b/src/core/components/execute.jsx
index 0c005fcbbb4..04765e91b9f 100644
--- a/src/core/components/execute.jsx
+++ b/src/core/components/execute.jsx
@@ -31,6 +31,7 @@ export default class Execute extends Component {
     let oas3RequiredRequestBodyContentType = specSelectors.getOAS3RequiredRequestBodyContentType([path, method])
     let oas3RequestBodyValue = oas3Selectors.requestBodyValue(path, method)
     let oas3ValidateBeforeExecuteSuccess = oas3Selectors.validateBeforeExecute([path, method])
+    let oas3RequestContentType = oas3Selectors.requestContentType(path, method)
 
     if (!oas3ValidateBeforeExecuteSuccess) {
       validationErrors.missingBodyValue = true
@@ -40,7 +41,11 @@ export default class Execute extends Component {
     if (!oas3RequiredRequestBodyContentType) {
       return true
     }
-    let missingRequiredKeys = oas3Selectors.validateShallowRequired({ oas3RequiredRequestBodyContentType, oas3RequestBodyValue })
+    let missingRequiredKeys = oas3Selectors.validateShallowRequired({
+      oas3RequiredRequestBodyContentType,
+      oas3RequestContentType,
+      oas3RequestBodyValue
+    })
     if (!missingRequiredKeys || missingRequiredKeys.length < 1) {
       return true
     }
diff --git a/src/core/components/parameters/parameters.jsx b/src/core/components/parameters/parameters.jsx
index 916e8471fbb..a1bb9eb61ba 100644
--- a/src/core/components/parameters/parameters.jsx
+++ b/src/core/components/parameters/parameters.jsx
@@ -77,6 +77,21 @@ export default class Parameters extends Component {
     }
   }
 
+  onChangeMediaType = ( { value, pathMethod } ) => {
+    let { specSelectors, specActions, oas3Selectors, oas3Actions } = this.props
+    let targetMediaType = value
+    let currentMediaType = oas3Selectors.requestContentType(...pathMethod)
+    let schemaPropertiesMatch = specSelectors.isMediaTypeSchemaPropertiesEqual(pathMethod, currentMediaType, targetMediaType)
+    if (!schemaPropertiesMatch) {
+      oas3Actions.clearRequestBodyValue({ pathMethod })
+      specActions.clearResponse(...pathMethod)
+      specActions.clearRequest(...pathMethod)
+      specActions.clearValidateParams(pathMethod)
+    }
+    oas3Actions.setRequestContentType({ value, pathMethod })
+    oas3Actions.initRequestBodyValidateError({ pathMethod })
+  }
+
   render(){
 
     let {
@@ -187,8 +202,7 @@ export default class Parameters extends Component {
                   value={oas3Selectors.requestContentType(...pathMethod)}
                   contentTypes={ requestBody.get("content", List()).keySeq() }
                   onChange={(value) => {
-                    oas3Actions.setRequestContentType({ value, pathMethod })
-                    oas3Actions.initRequestBodyValidateError({ pathMethod })
+                    this.onChangeMediaType({ value, pathMethod })
                   }}
                   className="body-param-content-type" />
               </label>
diff --git a/src/core/plugins/oas3/actions.js b/src/core/plugins/oas3/actions.js
index ef6a7ae6b9b..e0f3c256e85 100644
--- a/src/core/plugins/oas3/actions.js
+++ b/src/core/plugins/oas3/actions.js
@@ -10,6 +10,7 @@ export const UPDATE_RESPONSE_CONTENT_TYPE = "oas3_set_response_content_type"
 export const UPDATE_SERVER_VARIABLE_VALUE = "oas3_set_server_variable_value"
 export const SET_REQUEST_BODY_VALIDATE_ERROR = "oas3_set_request_body_validate_error"
 export const CLEAR_REQUEST_BODY_VALIDATE_ERROR = "oas3_clear_request_body_validate_error"
+export const CLEAR_REQUEST_BODY_VALUE = "oas3_clear_request_body_value"
 
 export function setSelectedServer (selectedServerUrl, namespace) {
   return {
@@ -80,3 +81,10 @@ export const initRequestBodyValidateError = ({ pathMethod } ) => {
     payload: { path: pathMethod[0], method: pathMethod[1] }
   }
 }
+
+export const clearRequestBodyValue = ({ pathMethod }) => {
+  return {
+    type:  CLEAR_REQUEST_BODY_VALUE,
+    payload: { pathMethod }
+  }
+}
diff --git a/src/core/plugins/oas3/reducers.js b/src/core/plugins/oas3/reducers.js
index 9951bf839d0..e317bbdcb03 100644
--- a/src/core/plugins/oas3/reducers.js
+++ b/src/core/plugins/oas3/reducers.js
@@ -10,6 +10,7 @@ import {
   UPDATE_RESPONSE_CONTENT_TYPE,
   SET_REQUEST_BODY_VALIDATE_ERROR,
   CLEAR_REQUEST_BODY_VALIDATE_ERROR,
+  CLEAR_REQUEST_BODY_VALUE,
 } from "./actions"
 
 export default {
@@ -94,4 +95,15 @@ export default {
       }, bodyValues)
     })
   },
+  [CLEAR_REQUEST_BODY_VALUE]: (state, { payload: { pathMethod }}) => {
+    let [path, method] = pathMethod
+    const requestBodyValue = state.getIn(["requestData", path, method, "bodyValue"])
+    if (!requestBodyValue) {
+      return state
+    }
+    if (!Map.isMap(requestBodyValue)) {
+      return state.setIn(["requestData", path, method, "bodyValue"], "")
+    }
+    return state.setIn(["requestData", path, method, "bodyValue"], Map())
+  }
 }
diff --git a/src/core/plugins/oas3/selectors.js b/src/core/plugins/oas3/selectors.js
index 1c5df118bfa..2176e2e52e6 100644
--- a/src/core/plugins/oas3/selectors.js
+++ b/src/core/plugins/oas3/selectors.js
@@ -154,23 +154,23 @@ export const validateBeforeExecute = validateRequestBodyIsRequired(
   (state, pathMethod) => validateRequestBodyValueExists(state, pathMethod)
 )
 
-export const validateShallowRequired = ( state, {oas3RequiredRequestBodyContentType, oas3RequestBodyValue} ) => {
+export const validateShallowRequired = (state, { oas3RequiredRequestBodyContentType, oas3RequestContentType, oas3RequestBodyValue} ) => {
   let missingRequiredKeys = []
-  // context: json => String; urlencoded => Map
+  // context: json => String; urlencoded, form-data => Map
   if (!Map.isMap(oas3RequestBodyValue)) {
     return missingRequiredKeys
   }
   let requiredKeys = []
-  // We intentionally cycle through list of contentTypes for defined requiredKeys
-  // instead of assuming first contentType will accurately list all expected requiredKeys
-  // Alternatively, we could try retrieving the contentType first, and match exactly. This would be a more accurate representation of definition
+  // Cycle through list of possible contentTypes for matching contentType and defined requiredKeys
   Object.keys(oas3RequiredRequestBodyContentType.requestContentType).forEach((contentType) => {
-    let contentTypeVal = oas3RequiredRequestBodyContentType.requestContentType[contentType]
-    contentTypeVal.forEach((requiredKey) => {
-      if (requiredKeys.indexOf(requiredKey) < 0 ) {
-        requiredKeys.push(requiredKey)
-      }
-    })
+    if (contentType === oas3RequestContentType) {
+      let contentTypeVal = oas3RequiredRequestBodyContentType.requestContentType[contentType]
+      contentTypeVal.forEach((requiredKey) => {
+        if (requiredKeys.indexOf(requiredKey) < 0 ) {
+          requiredKeys.push(requiredKey)
+        }
+      })
+    }
   })
   requiredKeys.forEach((key) => {
     let requiredKeyValue = oas3RequestBodyValue.getIn([key, "value"])
diff --git a/src/core/plugins/spec/selectors.js b/src/core/plugins/spec/selectors.js
index 2c854729b1b..f9d314dfaf0 100644
--- a/src/core/plugins/spec/selectors.js
+++ b/src/core/plugins/spec/selectors.js
@@ -514,6 +514,17 @@ export const getOAS3RequiredRequestBodyContentType = (state, pathMethod) => {
   return requiredObj
 }
 
+export const isMediaTypeSchemaPropertiesEqual = ( state, pathMethod, currentMediaType, targetMediaType) => {
+  let requestBodyContent = state.getIn(["resolvedSubtrees", "paths", ...pathMethod, "requestBody", "content"], fromJS([]))
+  if (requestBodyContent.size < 2 || !currentMediaType || !targetMediaType) {
+    // nothing to compare
+    return false
+  }
+  let currentMediaTypeSchemaProperties = requestBodyContent.getIn([currentMediaType, "schema", "properties"], fromJS([]))
+  let targetMediaTypeSchemaProperties = requestBodyContent.getIn([targetMediaType, "schema", "properties"], fromJS([]))
+  return currentMediaTypeSchemaProperties.equals(targetMediaTypeSchemaProperties) ? true: false
+}
+
 function returnSelfOrNewMap(obj) {
   // returns obj if obj is an Immutable map, else returns a new Map
   return Map.isMap(obj) ? obj : new Map()
diff --git a/test/e2e-cypress/static/documents/features/oas3-multiple-media-type.yaml b/test/e2e-cypress/static/documents/features/oas3-multiple-media-type.yaml
new file mode 100644
index 00000000000..280891ae9a2
--- /dev/null
+++ b/test/e2e-cypress/static/documents/features/oas3-multiple-media-type.yaml
@@ -0,0 +1,50 @@
+openapi: 3.0.0
+info:
+  title: Switching between multiple content-type test
+  version: 1.0.0
+servers:
+  - url: https://httpbin.org
+paths:
+  /post:
+    post:
+      requestBody:
+        content:
+          multipart/form-data:
+            schema:
+              $ref: '#/components/schemas/Bar'
+          application/x-www-form-urlencoded:
+            schema:
+              $ref: '#/components/schemas/Foo'
+          application/json:
+            schema:
+              $ref: '#/components/schemas/FooBar'
+      responses:
+        '200':
+          description: ok
+
+components:
+  schemas:
+    Foo:
+      type: object
+      properties:
+        foo:
+          type: string
+          example: ''
+    Bar:
+      type: object
+      required: [bar]
+      properties:
+        bar:
+          type: integer
+          example: 1
+    FooBar:
+      type: object
+      required:
+        - bar
+      properties:
+        foo:
+          type: string
+          example: ''
+        bar:
+          type: integer
+          example: 1
diff --git a/test/e2e-cypress/tests/features/oas3-multiple-media-type.js b/test/e2e-cypress/tests/features/oas3-multiple-media-type.js
new file mode 100644
index 00000000000..a70d4486bc7
--- /dev/null
+++ b/test/e2e-cypress/tests/features/oas3-multiple-media-type.js
@@ -0,0 +1,174 @@
+// https://github.com/swagger-api/swagger-ui/issues/6201
+// https://github.com/swagger-api/swagger-ui/issues/6250
+// https://github.com/swagger-api/swagger-ui/issues/6476
+
+describe("OpenAPI 3.0 Multiple Media Types with different schemas", () => {
+  const mediaTypeFormData = "multipart/form-data"
+  const mediaTypeUrlencoded = "application/x-www-form-urlencoded"
+  const mediaTypeJson = "application/json"
+
+  beforeEach(() => {
+    cy.visit(
+      "/?url=/documents/features/oas3-multiple-media-type.yaml"
+    )
+      .get("#operations-default-post_post")
+      .click()
+      // Expand Try It Out
+      .get(".try-out__btn")
+      .click()
+    // @alias Execute Button
+    cy.get(".execute.opblock-control__btn").as("executeBtn")
+    // @alias Media Type Dropdown
+    cy.get(".opblock-section-request-body .content-type").as("selectMediaType")
+  })
+
+  // In all cases, 
+  // - assume that examples are populated based on schema (not explicitly tested)
+  // - assume validation passes based on successful "execute"
+  // - expect final cURL command result doees not contain unexpected artifacts from other content-type schemas
+  describe("multipart/form-data (only 'bar')", () => {
+    it("should execute multipart/form-data", () => {
+      cy.get("@selectMediaType")
+        .select(mediaTypeFormData)
+      cy.get("@executeBtn")
+        .click()
+      // cURL component
+      cy.get(".responses-wrapper .curl-command")
+        .should("exist")
+        .get(".responses-wrapper .curl-command span")
+        .should("contains.text", "bar")
+        .should("not.contains.text", "foo")
+    })
+    it("should execute application/x-www-form-urlencoded THEN execute multipart/form-data", () => {
+      cy.get("@selectMediaType")
+        .select(mediaTypeUrlencoded)
+      cy.get("@executeBtn")
+        .click()
+      cy.get("@selectMediaType")
+        .select(mediaTypeFormData)
+      cy.get("@executeBtn")
+        .click()
+      // cURL component
+      cy.get(".responses-wrapper .curl-command")
+        .should("exist")
+        .get(".responses-wrapper .curl-command span")
+        .should("contains.text", "bar")
+        .should("not.contains.text", "foo")
+    })
+    it("should execute application/json THEN execute multipart/form-data", () => {
+      cy.get("@selectMediaType")
+        .select(mediaTypeJson)
+      cy.get("@executeBtn")
+        .click()
+      cy.get("@selectMediaType")
+        .select(mediaTypeFormData)
+      cy.get("@executeBtn")
+        .click()
+      // cURL component
+      cy.get(".responses-wrapper .curl-command")
+        .should("exist")
+        .get(".responses-wrapper .curl-command span")
+        .should("contains.text", "bar")
+        .should("not.contains.text", "foo")
+    })
+  })
+
+  describe("application/x-www-form-urlencoded (only 'foo')", () => {
+    it("should execute application/x-www-form-urlencoded", () => {
+      cy.get("@selectMediaType")
+        .select(mediaTypeUrlencoded)
+      cy.get("@executeBtn")
+        .click()
+      // cURL component
+      cy.get(".responses-wrapper .curl-command")
+        .should("exist")
+        .get(".responses-wrapper .curl-command span")
+        .should("contains.text", "foo")
+        .should("not.contains.text", "bar")
+    })
+    it("should execute multipart/form-data THEN execute application/x-www-form-urlencoded", () => {
+      cy.get("@selectMediaType")
+        .select(mediaTypeFormData)
+      cy.get("@executeBtn")
+        .click()
+      cy.get("@selectMediaType")
+        .select(mediaTypeUrlencoded)
+      cy.get("@executeBtn")
+        .click()
+      // cURL component
+      cy.get(".responses-wrapper .curl-command")
+        .should("exist")
+        .get(".responses-wrapper .curl-command span")
+        .should("contains.text", "foo")
+        .should("not.contains.text", "bar")
+    })
+    it("should execute application/json THEN execute application/x-www-form-urlencoded", () => {
+      cy.get("@selectMediaType")
+        .select(mediaTypeJson)
+      cy.get("@executeBtn")
+        .click()
+      cy.get("@selectMediaType")
+        .select(mediaTypeUrlencoded)
+      cy.get("@executeBtn")
+        .click()
+      // cURL component
+      cy.get(".responses-wrapper .curl-command")
+        .should("exist")
+        .get(".responses-wrapper .curl-command span")
+        .should("contains.text", "foo")
+        .should("not.contains.text", "bar")
+    })
+  })
+
+  describe("application/json (both 'foo' and 'bar')", () => {
+    // note: form input for "application/json" is a string; not multiple form fields
+    it("should execute application/json", () => {
+      // final curl should have both "bar" and "foo"
+      cy.get("@selectMediaType")
+        .select(mediaTypeJson)
+      cy.get("@executeBtn")
+        .click()
+      cy.get("@executeBtn")
+        .click()
+      // cURL component
+      cy.get(".responses-wrapper .curl-command")
+        .should("exist")
+        .get(".responses-wrapper .curl-command span")
+        .should("contains.text", "foo")
+        .should("contains.text", "bar")
+    })
+    it("should execute multipart/form-data THEN execute application/json", () => {
+      cy.get("@selectMediaType")
+        .select(mediaTypeFormData)
+      cy.get("@executeBtn")
+        .click()
+      cy.get("@selectMediaType")
+        .select(mediaTypeJson)
+      cy.get("@executeBtn")
+        .click()
+      // cURL component
+      cy.get(".responses-wrapper .curl-command")
+        .should("exist")
+        .get(".responses-wrapper .curl-command span")
+        .should("contains.text", "foo")
+        .should("contains.text", "bar")
+    })
+    it("should execute application/x-www-form-urlencoded THEN execute application/json", () => {
+      // final curl should have both "bar" and "foo"
+      cy.get("@selectMediaType")
+        .select(mediaTypeUrlencoded)
+      cy.get("@executeBtn")
+        .click()
+      cy.get("@selectMediaType")
+        .select(mediaTypeJson)
+      cy.get("@executeBtn")
+        .click()
+      // cURL component
+      cy.get(".responses-wrapper .curl-command")
+        .should("exist")
+        .get(".responses-wrapper .curl-command span")
+        .should("contains.text", "foo")
+        .should("contains.text", "bar")
+    })
+  })
+})
diff --git a/test/unit/core/plugins/oas3/reducers.js b/test/unit/core/plugins/oas3/reducers.js
index 102b25e3e8e..c99eaba1da8 100644
--- a/test/unit/core/plugins/oas3/reducers.js
+++ b/test/unit/core/plugins/oas3/reducers.js
@@ -504,4 +504,79 @@ describe("oas3 plugin - reducer", function () {
     })
   })
 
+  describe("CLEAR_REQUEST_BODY_VALUE", function () {
+    const clearRequestBodyValue = reducer["oas3_clear_request_body_value"]
+    describe("when requestBodyValue is a String", () => {
+      it("should clear requestBodyValue with empty String", () => {
+        const state = fromJS({
+          requestData: {
+            "/pet": {
+              post: {
+                bodyValue: "some random string",
+                requestContentType: "application/json"
+              }
+            }
+          }
+        })
+  
+        const result = clearRequestBodyValue(state, {
+          payload: {
+            pathMethod: ["/pet", "post"],
+          }
+        })
+  
+        const expectedResult = {
+          requestData: {
+            "/pet": {
+              post: {
+                bodyValue: "",
+                requestContentType: "application/json",
+              }
+            }
+          }
+        }
+  
+        expect(result.toJS()).toEqual(expectedResult)
+      })
+    })
+
+    describe("when requestBodyValue is a Map", () => {
+      it("should clear requestBodyValue with empty Map", () => {
+        const state = fromJS({
+          requestData: {
+            "/pet": {
+              post: {
+                bodyValue: {
+                  id: {
+                    value: "10",
+                  },
+                },
+                requestContentType: "application/x-www-form-urlencoded"
+              }
+            }
+          }
+        })
+  
+        const result = clearRequestBodyValue(state, {
+          payload: {
+            pathMethod: ["/pet", "post"],
+          }
+        })
+  
+        const expectedResult = {
+          requestData: {
+            "/pet": {
+              post: {
+                bodyValue: {},
+                requestContentType: "application/x-www-form-urlencoded",
+              }
+            }
+          }
+        }
+  
+        expect(result.toJS()).toEqual(expectedResult)
+      })
+    })
+  })
+
 })