diff --git a/docs/api-reference.md b/docs/api-reference.md
index 337871e3..33ca1c62 100644
--- a/docs/api-reference.md
+++ b/docs/api-reference.md
@@ -9,6 +9,7 @@ route: '/reference/api'
 
 - [`renderHook`](/reference/api#renderhook)
 - [`act`](/reference/api#act)
+- [`cleanup`](/reference/api#cleanup)
 
 ---
 
@@ -102,3 +103,23 @@ A function to unmount the test component. This is commonly used to trigger clean
 
 This is the same [`act` function](https://reactjs.org/docs/test-utils.html#act) that is exported by
 `react-test-renderer`.
+
+---
+
+## `cleanup`
+
+```js
+function cleanup: Promise<void>
+```
+
+Unmounts any rendered hooks rendered with `renderHook`, ensuring all effects have been flushed.
+
+> Please note that this is done automatically if the testing framework you're using supports the
+> `afterEach` global (like mocha, Jest, and Jasmine). If not, you will need to do manual cleanups
+> after each test.
+>
+> Setting the `RHTL_SKIP_AUTO_CLEANUP` environment variable to `true` before the
+> `@testing-library/react-hooks` is imported will disable this feature.
+
+The `cleanup` function should be called after each test to ensure that previously rendered hooks
+will not have any unintended side-effects on the following tests.
diff --git a/src/cleanup.js b/src/cleanup.js
new file mode 100644
index 00000000..c4f71e8e
--- /dev/null
+++ b/src/cleanup.js
@@ -0,0 +1,26 @@
+import { act } from 'react-test-renderer'
+
+let cleanupCallbacks = []
+
+async function cleanup() {
+  await act(async () => {})
+  cleanupCallbacks.forEach((cb) => cb())
+  cleanupCallbacks = []
+}
+
+function addCleanup(callback) {
+  cleanupCallbacks.push(callback)
+}
+
+function removeCleanup(callback) {
+  cleanupCallbacks = cleanupCallbacks.filter((cb) => cb !== callback)
+}
+
+// Automatically registers cleanup in supported testing frameworks
+if (typeof afterEach === 'function' && !process.env.RHTL_SKIP_AUTO_CLEANUP) {
+  afterEach(async () => {
+    await cleanup()
+  })
+}
+
+export { cleanup, addCleanup, removeCleanup }
diff --git a/src/index.js b/src/index.js
index f4411f5b..f33d362f 100644
--- a/src/index.js
+++ b/src/index.js
@@ -1,5 +1,6 @@
 import React, { Suspense } from 'react'
 import { act, create } from 'react-test-renderer'
+import { cleanup, addCleanup, removeCleanup } from './cleanup'
 
 function TestHook({ callback, hookProps, onError, children }) {
   try {
@@ -73,6 +74,15 @@ function renderHook(callback, { initialProps, wrapper } = {}) {
   })
   const { unmount, update } = testRenderer
 
+  function unmountHook() {
+    act(() => {
+      removeCleanup(unmountHook)
+      unmount()
+    })
+  }
+
+  addCleanup(unmountHook)
+
   let waitingForNextUpdate = null
   const resolveOnNextUpdate = (resolve) => {
     addResolver((...args) => {
@@ -93,12 +103,8 @@ function renderHook(callback, { initialProps, wrapper } = {}) {
         update(toRender())
       })
     },
-    unmount: () => {
-      act(() => {
-        unmount()
-      })
-    }
+    unmount: unmountHook
   }
 }
 
-export { renderHook, act }
+export { renderHook, cleanup, act }
diff --git a/test/autoCleanup.disabled.test.js b/test/autoCleanup.disabled.test.js
new file mode 100644
index 00000000..7da342d5
--- /dev/null
+++ b/test/autoCleanup.disabled.test.js
@@ -0,0 +1,28 @@
+import { useEffect } from 'react'
+
+// This verifies that if RHTL_SKIP_AUTO_CLEANUP is set
+// then we DON'T auto-wire up the afterEach for folks
+describe('skip auto cleanup (disabled) tests', () => {
+  let cleanupCalled = false
+  let renderHook
+
+  beforeAll(() => {
+    process.env.RHTL_SKIP_AUTO_CLEANUP = 'true'
+    renderHook = require('src').renderHook
+  })
+
+  test('first', () => {
+    const hookWithCleanup = () => {
+      useEffect(() => {
+        return () => {
+          cleanupCalled = true
+        }
+      })
+    }
+    renderHook(() => hookWithCleanup())
+  })
+
+  test('second', () => {
+    expect(cleanupCalled).toBe(false)
+  })
+})
diff --git a/test/autoCleanup.noAfterEach.test.js b/test/autoCleanup.noAfterEach.test.js
new file mode 100644
index 00000000..c1f51eea
--- /dev/null
+++ b/test/autoCleanup.noAfterEach.test.js
@@ -0,0 +1,28 @@
+import { useEffect } from 'react'
+
+// This verifies that if RHTL_SKIP_AUTO_CLEANUP is set
+// then we DON'T auto-wire up the afterEach for folks
+describe('skip auto cleanup (no afterEach) tests', () => {
+  let cleanupCalled = false
+  let renderHook
+
+  beforeAll(() => {
+    afterEach = false
+    renderHook = require('src').renderHook
+  })
+
+  test('first', () => {
+    const hookWithCleanup = () => {
+      useEffect(() => {
+        return () => {
+          cleanupCalled = true
+        }
+      })
+    }
+    renderHook(() => hookWithCleanup())
+  })
+
+  test('second', () => {
+    expect(cleanupCalled).toBe(false)
+  })
+})
diff --git a/test/autoCleanup.test.js b/test/autoCleanup.test.js
new file mode 100644
index 00000000..fc70d111
--- /dev/null
+++ b/test/autoCleanup.test.js
@@ -0,0 +1,24 @@
+import { useEffect } from 'react'
+import { renderHook } from 'src'
+
+// This verifies that by importing RHTL in an
+// environment which supports afterEach (like jest)
+// we'll get automatic cleanup between tests.
+describe('auto cleanup tests', () => {
+  let cleanupCalled = false
+
+  test('first', () => {
+    const hookWithCleanup = () => {
+      useEffect(() => {
+        return () => {
+          cleanupCalled = true
+        }
+      })
+    }
+    renderHook(() => hookWithCleanup())
+  })
+
+  test('second', () => {
+    expect(cleanupCalled).toBe(true)
+  })
+})
diff --git a/test/cleanup.test.js b/test/cleanup.test.js
new file mode 100644
index 00000000..a8c3bbba
--- /dev/null
+++ b/test/cleanup.test.js
@@ -0,0 +1,41 @@
+import { useEffect } from 'react'
+import { renderHook, cleanup } from 'src'
+
+describe('cleanup tests', () => {
+  test('should flush effects on cleanup', async () => {
+    let cleanupCalled = false
+
+    const hookWithCleanup = () => {
+      useEffect(() => {
+        return () => {
+          cleanupCalled = true
+        }
+      })
+    }
+
+    renderHook(() => hookWithCleanup())
+
+    await cleanup()
+
+    expect(cleanupCalled).toBe(true)
+  })
+
+  test('should cleanup all rendered hooks', async () => {
+    let cleanupCalled = []
+    const hookWithCleanup = (id) => {
+      useEffect(() => {
+        return () => {
+          cleanupCalled[id] = true
+        }
+      })
+    }
+
+    renderHook(() => hookWithCleanup(1))
+    renderHook(() => hookWithCleanup(2))
+
+    await cleanup()
+
+    expect(cleanupCalled[1]).toBe(true)
+    expect(cleanupCalled[2]).toBe(true)
+  })
+})