diff --git a/tests/v1/entrypoints/llm/test_struct_output_generate.py b/tests/v1/entrypoints/llm/test_struct_output_generate.py
index d2569959114..c3ea024f58c 100644
--- a/tests/v1/entrypoints/llm/test_struct_output_generate.py
+++ b/tests/v1/entrypoints/llm/test_struct_output_generate.py
@@ -81,6 +81,9 @@ def test_structured_output(
 ):
     monkeypatch.setenv("VLLM_USE_V1", "1")
 
+    if current_platform.is_tpu() and speculative_config:
+        pytest.skip("TPU does not support speculative decoding")
+
     # Don't use eager execution on TPUs because we want to test for no
     # recompilation at runtime
     enforce_eager = bool(not current_platform.is_tpu())