diff --git a/subsys/usb/class/bluetooth.c b/subsys/usb/class/bluetooth.c
index d9294dc33ef6..78bb48de92d4 100644
--- a/subsys/usb/class/bluetooth.c
+++ b/subsys/usb/class/bluetooth.c
@@ -263,7 +263,8 @@ static int bluetooth_class_handler(struct usb_setup_packet *setup,
 
 static void bluetooth_interface_config(u8_t bInterfaceNumber)
 {
-	bluetooth_cfg.if0.bInterfaceNumber = bInterfaceNumber;
+	UNALIGNED_PUT(bInterfaceNumber,
+		      &bluetooth_cfg.if0.bInterfaceNumber);
 }
 
 USBD_CFG_DATA_DEFINE(hci) struct usb_cfg_data bluetooth_config = {
diff --git a/subsys/usb/class/cdc_acm.c b/subsys/usb/class/cdc_acm.c
index fb2ad8366bbe..0cc3e1eb38c3 100644
--- a/subsys/usb/class/cdc_acm.c
+++ b/subsys/usb/class/cdc_acm.c
@@ -427,12 +427,17 @@ static void cdc_acm_dev_status_cb(enum usb_dc_status_code status, u8_t *param)
 
 static void cdc_interface_config(u8_t bInterfaceNumber)
 {
-	cdc_acm_cfg.if0.bInterfaceNumber = bInterfaceNumber;
-	cdc_acm_cfg.if0_union.bControlInterface = bInterfaceNumber;
-	cdc_acm_cfg.if1.bInterfaceNumber = bInterfaceNumber + 1;
-	cdc_acm_cfg.if0_union.bSubordinateInterface0 = bInterfaceNumber + 1;
+	UNALIGNED_PUT(bInterfaceNumber,
+		      &cdc_acm_cfg.if0.bInterfaceNumber);
+	UNALIGNED_PUT(bInterfaceNumber,
+		      &cdc_acm_cfg.if0_union.bControlInterface);
+	UNALIGNED_PUT((bInterfaceNumber + 1),
+		      &cdc_acm_cfg.if1.bInterfaceNumber);
+	UNALIGNED_PUT((bInterfaceNumber + 1),
+		      &cdc_acm_cfg.if0_union.bSubordinateInterface0);
 #ifdef CONFIG_USB_COMPOSITE_DEVICE
-	cdc_acm_cfg.iad_cdc.bFirstInterface = bInterfaceNumber;
+	UNALIGNED_PUT(bInterfaceNumber,
+		      &cdc_acm_cfg.iad_cdc.bFirstInterface);
 #endif
 }
 
diff --git a/subsys/usb/class/hid/core.c b/subsys/usb/class/hid/core.c
index 7914a11d7d5b..8cfa4d2a994f 100644
--- a/subsys/usb/class/hid/core.c
+++ b/subsys/usb/class/hid/core.c
@@ -68,8 +68,8 @@ USBD_CLASS_DESCR_DEFINE(primary) struct usb_hid_config hid_cfg = {
 
 static void usb_set_hid_report_size(u16_t report_desc_size)
 {
-	hid_cfg.if0_hid.subdesc[0].wDescriptorLength =
-		sys_cpu_to_le16(report_desc_size);
+	UNALIGNED_PUT(sys_cpu_to_le16(report_desc_size),
+		      &hid_cfg.if0_hid.subdesc[0].wDescriptorLength);
 }
 
 static struct hid_device_info {
@@ -211,7 +211,8 @@ static struct usb_ep_cfg_data hid_ep_data[] = {
 
 static void hid_interface_config(u8_t bInterfaceNumber)
 {
-	hid_cfg.if0.bInterfaceNumber = bInterfaceNumber;
+	UNALIGNED_PUT(bInterfaceNumber,
+		      &hid_cfg.if0.bInterfaceNumber);
 }
 
 USBD_CFG_DATA_DEFINE(hid) struct usb_cfg_data hid_config = {
diff --git a/subsys/usb/class/mass_storage.c b/subsys/usb/class/mass_storage.c
index 0e37a5913e0a..81fdac47c78c 100644
--- a/subsys/usb/class/mass_storage.c
+++ b/subsys/usb/class/mass_storage.c
@@ -818,7 +818,8 @@ static void mass_storage_status_cb(enum usb_dc_status_code status, u8_t *param)
 
 static void mass_interface_config(u8_t bInterfaceNumber)
 {
-	mass_cfg.if0.bInterfaceNumber = bInterfaceNumber;
+	UNALIGNED_PUT(bInterfaceNumber,
+		      &mass_cfg.if0.bInterfaceNumber);
 }
 
 /* Configuration of the Mass Storage Device send to the USB Driver */
diff --git a/subsys/usb/class/netusb/netusb.c b/subsys/usb/class/netusb/netusb.c
index 39b4e8542b60..ef56929f738a 100644
--- a/subsys/usb/class/netusb/netusb.c
+++ b/subsys/usb/class/netusb/netusb.c
@@ -367,29 +367,42 @@ static void netusb_interface_config(u8_t bInterfaceNumber)
 
 	if (idx) {
 		SYS_LOG_DBG("fixup string %d", idx);
-		cdc_ecm_cfg.if0_netfun_ecm.iMACAddress = idx;
+		UNALIGNED_PUT(idx,
+			      &cdc_ecm_cfg.if0_netfun_ecm.iMACAddress);
 	}
 
-	cdc_ecm_cfg.if0.bInterfaceNumber = bInterfaceNumber;
-	cdc_ecm_cfg.if0_union.bControlInterface = bInterfaceNumber;
-	cdc_ecm_cfg.if0_union.bSubordinateInterface0 = bInterfaceNumber + 1;
-	cdc_ecm_cfg.if1_0.bInterfaceNumber = bInterfaceNumber + 1;
-	cdc_ecm_cfg.if1_1.bInterfaceNumber = bInterfaceNumber + 1;
+	UNALIGNED_PUT(bInterfaceNumber,
+		      &cdc_ecm_cfg.if0.bInterfaceNumber);
+	UNALIGNED_PUT(bInterfaceNumber,
+		      &cdc_ecm_cfg.if0_union.bControlInterface);
+	UNALIGNED_PUT((bInterfaceNumber + 1),
+		      &cdc_ecm_cfg.if0_union.bSubordinateInterface0);
+	UNALIGNED_PUT((bInterfaceNumber + 1),
+		      &cdc_ecm_cfg.if1_0.bInterfaceNumber);
+	UNALIGNED_PUT((bInterfaceNumber + 1),
+		      &cdc_ecm_cfg.if1_1.bInterfaceNumber);
 #ifdef CONFIG_USB_COMPOSITE_DEVICE
-	cdc_ecm_cfg.iad.bFirstInterface = bInterfaceNumber;
+	UNALIGNED_PUT(bInterfaceNumber,
+		      &cdc_ecm_cfg.iad.bFirstInterface);
 #endif
 #endif
 #ifdef CONFIG_USB_DEVICE_NETWORK_RNDIS
-	rndis_cfg.if0.bInterfaceNumber = bInterfaceNumber;
-	rndis_cfg.if0_union.bControlInterface = bInterfaceNumber;
-	rndis_cfg.if0_union.bSubordinateInterface0 = bInterfaceNumber + 1;
-	rndis_cfg.if1.bInterfaceNumber = bInterfaceNumber + 1;
+	UNALIGNED_PUT(bInterfaceNumber,
+		      &rndis_cfg.if0.bInterfaceNumber);
+	UNALIGNED_PUT(bInterfaceNumber,
+		      &rndis_cfg.if0_union.bControlInterface);
+	UNALIGNED_PUT((bInterfaceNumber + 1),
+		      &rndis_cfg.if0_union.bSubordinateInterface0);
+	UNALIGNED_PUT((bInterfaceNumber + 1),
+		      &rndis_cfg.if1.bInterfaceNumber);
 #ifdef CONFIG_USB_COMPOSITE_DEVICE
-	rndis_cfg.iad.bFirstInterface = bInterfaceNumber;
+	UNALIGNED_PUT(bInterfaceNumber,
+		      &rndis_cfg.iad.bFirstInterface);
 #endif
 #endif
 #ifdef CONFIG_USB_DEVICE_NETWORK_EEM
-	cdc_eem_cfg.if0.bInterfaceNumber = bInterfaceNumber;
+	UNALIGNED_PUT(bInterfaceNumber,
+		      &cdc_eem_cfg.if0.bInterfaceNumber);
 #endif
 }
 
diff --git a/subsys/usb/class/usb_dfu.c b/subsys/usb/class/usb_dfu.c
index c808efcaf914..00cdfdcc1e5a 100644
--- a/subsys/usb/class/usb_dfu.c
+++ b/subsys/usb/class/usb_dfu.c
@@ -646,7 +646,8 @@ static int dfu_custom_handle_req(struct usb_setup_packet *pSetup,
 
 static void dfu_interface_config(u8_t bInterfaceNumber)
 {
-	dfu_cfg.if0.bInterfaceNumber = bInterfaceNumber;
+	UNALIGNED_PUT(bInterfaceNumber,
+		      &dfu_cfg.if0.bInterfaceNumber);
 }
 
 /* Configuration of the DFU Device send to the USB Driver */
diff --git a/subsys/usb/usb_descriptor.c b/subsys/usb/usb_descriptor.c
index f95d8953ff92..cd58a85ea241 100644
--- a/subsys/usb/usb_descriptor.c
+++ b/subsys/usb/usb_descriptor.c
@@ -247,7 +247,8 @@ static int usb_validate_ep_cfg_data(struct usb_ep_descriptor * const ep_descr,
 				ep_cfg.ep_addr = idx;
 			}
 			if (!usb_dc_ep_check_cap(&ep_cfg)) {
-				ep_descr->bEndpointAddress = ep_cfg.ep_addr;
+				UNALIGNED_PUT(ep_cfg.ep_addr,
+					      &ep_descr->bEndpointAddress);
 				ep_data[i].ep_addr = ep_cfg.ep_addr;
 				if (ep_cfg.ep_addr & USB_EP_DIR_IN) {
 					*requested_ep |= (1 << (idx + 16));
@@ -354,12 +355,12 @@ static int usb_fix_descriptor(struct usb_desc_header *head)
 			if (str_descr_idx) {
 				ascii7_to_utf16le(head);
 			} else {
-				SYS_LOG_DBG("Now the wTotalLength is %d",
-					    (u8_t *)head - (u8_t *)cfg_descr);
-				cfg_descr->wTotalLength =
-					sys_cpu_to_le16((u8_t *)head -
-							(u8_t *)cfg_descr);
-				cfg_descr->bNumInterfaces = numof_ifaces;
+				u16_t dlen = (u8_t *)head - (u8_t *)cfg_descr;
+
+				SYS_LOG_DBG("Now the wTotalLength is %d", dlen);
+				UNALIGNED_PUT(dlen, &cfg_descr->wTotalLength);
+				UNALIGNED_PUT(numof_ifaces,
+					      &cfg_descr->bNumInterfaces);
 			}
 
 			str_descr_idx += 1;